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Verfasst von:Chamulitrat, Walee [VerfasserIn]   i
 Jansakun, Chutima [VerfasserIn]   i
 Li, Huili [VerfasserIn]   i
 Liebisch, Gerhard [VerfasserIn]   i
Titel:Rescue of hepatic phospholipid remodeling defect in iPLA2β-null mice attenuates obese but not non-obese fatty liver
Verf.angabe:Walee Chamulitrat, Chutima Jansakun, Huili Li and Gerhard Liebisch
E-Jahr:2020
Jahr:17 September 2020
Umfang:25 S.
Fussnoten:Im Titel ist die Ziffer 2 tiefgestellt ; Gesehen am 16.11.2020
Titel Quelle:Enthalten in: Biomolecules
Ort Quelle:Basel : MDPI, 2011
Jahr Quelle:2020
Band/Heft Quelle:10(2020,9) Artikel-Nummer 1332, 25 Seiten
ISSN Quelle:2218-273X
Abstract:Polymorphisms of group VIA calcium-independent phospholipase A2 (iPLA2β or PLA2G6) are positively associated with adiposity, blood lipids, and Type-2 diabetes. The ubiquitously expressed iPLA2β catalyzes the hydrolysis of phospholipids (PLs) to generate a fatty acid and a lysoPL. We studied the role of iPLA2β on PL metabolism in non-alcoholic fatty liver disease (NAFLD). By using global deletion iPLA2β-null mice, we investigated three NAFLD mouse models; genetic Ob/Ob and long-term high-fat-diet (HFD) feeding (representing obese NAFLD) as well as feeding with methionine- and choline-deficient (MCD) diet (representing non-obese NAFLD). A decrease of hepatic PLs containing monounsaturated- and polyunsaturated fatty acids and a decrease of the ratio between PLs and cholesterol esters were observed in all three NAFLD models. iPLA2β deficiency rescued these decreases in obese, but not in non-obese, NAFLD models. iPLA2β deficiency elicited protection against fatty liver and obesity in the order of Ob/Ob › HFD » MCD. Liver inflammation was not protected in HFD NAFLD, and that liver fibrosis was even exaggerated in non-obese MCD model. Thus, the rescue of hepatic PL remodeling defect observed in iPLA2β-null mice was critical for the protection against NAFLD and obesity. However, iPLA2β deletion in specific cell types such as macrophages may render liver inflammation and fibrosis, independent of steatosis protection.
DOI:doi:10.3390/biom10091332
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.3390/biom10091332
 Volltext: https://www.mdpi.com/2218-273X/10/9/1332
 DOI: https://doi.org/10.3390/biom10091332
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:choline and methionine deficiency
 diet-induced obesity
 fatty liver
 morbidly obesity
 phospholipid remodeling
 PLA2G6
K10plus-PPN:1738742180
Verknüpfungen:→ Zeitschrift

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