No DDRama at chromosome ends

• Verfasst von: Feuerhahn, Sascha [VerfasserIn]
• Verfasst von: Chen, Liuh-yow [VerfasserIn]
• Verfasst von: Luke, Brian [VerfasserIn]
• Verfasst von: Porro, Antonio [VerfasserIn]
• Titel: No DDRama at chromosome ends
• Titelzusatz: TRF2 takes centre stage
• Verf.angabe: Sascha Feuerhahn, Liuh-yow Chen, Brian Luke, and Antonio Porro
• E-Jahr: 2015
• Jahr: 3 April 2015
• Umfang: 11 S.
• Fussnoten: Gesehen am 17.11.2020
• Titel Quelle: Enthalten in: Trends in biochemical sciences
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1976
• Jahr Quelle: 2015
• Band/Heft Quelle: 40(2015), 5, Seite 275-285
• ISSN Quelle: 1362-4326
• DOI: doi:10.1016/j.tibs.2015.03.003
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: chromatin
• Sach-SW: DNA damage response
• Sach-SW: t-loops
• Sach-SW: telomeres
• Sach-SW: TERRA
• Sach-SW: TRF2
• K10plus-PPN: 1738892271

Abstract

Telomeres are nucleoprotein structures capping the natural termini of eukaryotic linear chromosomes. Telomeres possess an inherent ability to circumvent the activation of a full-blown DNA damage response (DDR), and hence fusion reactions, by limiting inappropriate double-strand break (DSB) repair and processing activities at eukaryotic chromosome ends. A telomere-specific protein complex, termed shelterin, has a crucial function in safeguarding and securing telomere integrity. Within this complex, TRF2 has emerged as the key player, dictating different states of telomere protection during the replicative lifespan of a cell. How TRF2 prevents activation of DSB repair activities at functional telomeres has now been extensively investigated. In this review we aim at exploring the complex and multi-faceted mechanisms underlying the TRF2-mediated protection of eukaryotic chromosome ends.