The role of the proteasome activator PA28 in MHC class I antigen processing

• Verfasst von: Sijts, Elisabeth Joanna Anna Maria [VerfasserIn]
• Verfasst von: Sun, Yuansheng [VerfasserIn]
• Verfasst von: Paschen, Annette [VerfasserIn]
• Verfasst von: Schadendorf, Dirk [VerfasserIn]
• Titel: The role of the proteasome activator PA28 in MHC class I antigen processing
• Verf.angabe: Alice Sijts, Yuancheng Sun, Katarina Janek, Sylvie Kral, Annette Paschen, Dirk Schadendorf, Peter-M. Kloetzel
• E-Jahr: 2002
• Jahr: 21 August 2002
• Umfang: 5 S.
• Fussnoten: Gesehen am 17.11.2020
• Titel Quelle: Enthalten in: Molecular immunology
• Ort Quelle: Amsterdam [u.a.] : Elsevier, 1979
• Jahr Quelle: 2002
• Band/Heft Quelle: 39(2002), 3, Seite 165-169
• ISSN Quelle: 1872-9142
• DOI: doi:10.1016/S0161-5890(02)00099-8
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Major histocompatibility complex class I (MHC class I)
• Sach-SW: Proteasome activator PA28
• Sach-SW: Tumor antigen
• K10plus-PPN: 173890993X

Abstract

The proteasome system is the major source for the generation of viral antigens and tumor antigens presented by major histocompatibility complex class I (MHC class I) molecules. A specific feature of the proteasomal antigen processing machinery is that five of its components are inducible by IFN-γ. Two of these are the α and β subunits of the proteasome activator PA28. Our results show that PA28 selectively up-regulates the presentation of viral MHC class I epitopes and that down regulation PA28 in tumor cells results in impaired presentation of a human TRP2 tumor antigen.