Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Paschen, Annette [VerfasserIn]   i
 Sucker, Antje [VerfasserIn]   i
 Song, Mingxia [VerfasserIn]   i
 Schadendorf, Dirk [VerfasserIn]   i
Titel:Complete loss of HLA class I antigen expression on melanoma cells
Titelzusatz:A result of successive mutational events
Verf.angabe:Annette Paschen, Rosa María Méndez, Pilar Jimenez, Antje Sucker, Francisco Ruiz‐Cabello, Mingxia Song, Federico Garrido and Dirk Schadendorf
Jahr:2003
Jahr des Originals:2002
Umfang:9 S.
Fussnoten:First published: 12 December 2002 ; Gesehen am 17.11.2020
Titel Quelle:Enthalten in: International journal of cancer
Ort Quelle:Bognor Regis : Wiley-Liss, 1966
Jahr Quelle:2003
Band/Heft Quelle:103(2003), 6, Seite 759-767
ISSN Quelle:1097-0215
Abstract:Alterations in the surface expression of HLA class I molecules have been described as a strategy of tumors to evade recognition by cytotoxic T cells. We detected complete loss of HLA class I antigen presentation for 2 tumor cell lines from 1 melanoma patient, the first originated from a regional lymph node lesion diagnosed simultaneously with the primary tumor and the second established 8 months later from a metastatic pleural effusion sample. Antigen presentation was not inducible with IFN-γ but could be restored after transfection of tumor cells with b2m cDNA, indicating a defect in b2m expression. Analysis of the nature of this defect revealed that it originated from at least 2 mutational events affecting both copies of the b2m gene: a microdeletion of 498 bp in one b2m gene, including its entire exon 1, and a macrodeletion involving the entire copy of the second b2m gene. Microsatellite analysis pointed to the macrodeletion by demonstrating LOH for several specific markers on the long arm (q) of chromosome 15. Structural imbalance of 15q was verified by FISH. FISH studies also indicated the coexistence of a structurally abnormal variant of chromosome 15q with 2 apparently entire chromosomes 15q harboring the homozygous b2m microdeletion. Block of b2m expression in tumor cells builds a barrier to immunotherapy of cancer patients, and its early incidence should be of major consideration in the development and design of immunotherapeutic strategies. © 2002 Wiley-Liss, Inc.
DOI:doi:10.1002/ijc.10906
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/https://doi.org/10.1002/ijc.10906
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.10906
 DOI: https://doi.org/10.1002/ijc.10906
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:chromosomal aberration
 HLA loss
 immune escape
 mutation
 β2-microglobulin
K10plus-PPN:1738934713
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68661765   QR-Code
zum Seitenanfang