Some issues of sample size calculation for time-to-event endpoints using the Freedman and Schoenfeld formulas

• Verfasst von: Abel, Ulrich [VerfasserIn]
• Verfasst von: Jensen, Katrin [VerfasserIn]
• Verfasst von: Karapanagiotou-Schenkel, Irini [VerfasserIn]
• Verfasst von: Kieser, Meinhard [VerfasserIn]
• Titel: Some issues of sample size calculation for time-to-event endpoints using the Freedman and Schoenfeld formulas
• Verf.angabe: Ulrich R. Abel, Katrin Jensen, Irini Karapanagiotou-Schenkel & Meinhard Kieser
• E-Jahr: 2015
• Jahr: 30 Jul 2015
• Umfang: 27 S.
• Fussnoten: Gesehen am 18.11.2020
• Titel Quelle: Enthalten in: Journal of biopharmaceutical statistics
• Ort Quelle: Philadelphia, PA : Taylor & Francis, 1991
• Jahr Quelle: 2015
• Band/Heft Quelle: 25(2015), 6, Seite 1285-1311
• ISSN Quelle: 1520-5711
• DOI: doi:10.1080/10543406.2014.1000546
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Controlled clinical trial
• Sach-SW: Freedman formula
• Sach-SW: Sample size
• Sach-SW: Schoenfeld formula
• Sach-SW: Time-to-event data
• K10plus-PPN: 1739065662

Abstract

This article deals with seven special issues related to the assumptions, applicability, and practical use of formulas for calculating power or sample size, respectively, for comparative clinical trials with time-to-event endpoints, with particular focus on the well-known Freedman and Schoenfeld methods. All problems addressed are illustrated by numerical examples, and recommendations are given on how to deal with them in the planning of clinical trials.