Arthralgia induced by BRAF inhibitor therapy in melanoma patients

• Verfasst von: Salzmann, Martin [VerfasserIn]
• Verfasst von: Gente, Karolina [VerfasserIn]
• Verfasst von: Buder-Bakhaya, Kristina [VerfasserIn]
• Verfasst von: Papamichail, Dimitrios [VerfasserIn]
• Verfasst von: Dimitrakopoulou-Strauss, Antonia [VerfasserIn]
• Verfasst von: Lorenz, Hanns-Martin [VerfasserIn]
• Verfasst von: Enk, Alexander [VerfasserIn]
• Verfasst von: Hassel, Jessica C. [VerfasserIn]
• Titel: Arthralgia induced by BRAF inhibitor therapy in melanoma patients
• Verf.angabe: Martin Salzmann, Karolina Benesova, Kristina Buder-Bakhaya, Dimitrios Papamichail, Antonia Dimitrakopoulou-Strauss, Hanns-Martin Lorenz, Alexander H. Enk, Jessica C. Hassel
• E-Jahr: 2020
• Jahr: 16 October 2020
• Umfang: 15 S.
• Fussnoten: Gesehen am 23.11.2020
• Titel Quelle: Enthalten in: Cancers
• Ort Quelle: Basel : MDPI, 2009
• Jahr Quelle: 2020
• Band/Heft Quelle: 12(2020,10) Artikel-Nummer 3004, 15 Seiten
• ISSN Quelle: 2072-6694
• DOI: doi:10.3390/cancers12103004
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: arthralgia
• Sach-SW: BRAF
• Sach-SW: BRAF inhibitor
• Sach-SW: melanoma
• Sach-SW: rheumatoid arthritis
• K10plus-PPN: 1740368843

Abstract

Introduction: BRAF inhibitors (BRAFi), commonly used in BRAF-mutated metastatic melanoma (MM) treatment, frequently cause arthralgia. Although this is one of the most common side effects, it has not been characterized yet. Methods: We retrospectively included all patients treated with BRAFi +/− MEK inhibitors (MEKi) for MM at the National Center for Tumor Diseases (Heidelberg) between 2010 and 2018 and reviewed patient charts for the occurrence and management of arthralgia. The evaluation was supplemented by an analysis of frozen sera. Results: We included 154 patients (63% males); 31% (48/154) of them reported arthralgia with a median onset of 21 days after the start of the therapy. Arthralgia mostly affected small joints (27/36, 75%) and less frequently large joints (19/36, 53%). The most commonly affected joints were in fingers (19/36, 53%), wrists (16/36, 44%), and knees (12/36, 33%). In 67% (24/36) of the patients, arthralgia occurred with a symmetrical polyarthritis, mainly of small joints, resembling the pattern typically observed in patients affected by rheumatoid arthritis (RA), for which a role of the MAPK signaling pathway was previously described. Patients were negative for antinuclear antibodies, anti-citrullinated protein antibodies, and rheumatoid factor; arthritis was visible in 10 of 13 available PET–CT scans. The development of arthralgia was linked to better progression-free survival and overall survival. Conclusion: Arthralgia is a common side effect in patients receiving BRAFi +/− MEKi therapy and often presents a clinical pattern similar to that observed in RA patients. Its occurrence was associated with longer-lasting tumor control.