Positron emission tomography in merkel cell carcinoma

• Verfasst von: Sachpekidis, Christos [VerfasserIn]
• Verfasst von: Sidiropoulou, Polytimi [VerfasserIn]
• Verfasst von: Hassel, Jessica C. [VerfasserIn]
• Verfasst von: Drakoulis, Nikolaos [VerfasserIn]
• Verfasst von: Dimitrakopoulou-Strauss, Antonia [VerfasserIn]
• Titel: Positron emission tomography in merkel cell carcinoma
• Verf.angabe: Christos Sachpekidis, Polytimi Sidiropoulou, Jessica C. Hassel, Nikolaos Drakoulis and Antonia Dimitrakopoulou-Strauss
• E-Jahr: 2020
• Jahr: 9 October 2020
• Umfang: 18 S.
• Teil: volume:12
• Teil: year:2020
• Teil: number:10
• Teil: extent:18
• Fussnoten: Gesehen am 24.11.2020
• Titel Quelle: Enthalten in: Cancers
• Ort Quelle: Basel : MDPI, 2009
• Jahr Quelle: 2020
• Band/Heft Quelle: 12(2020,10) Artikel-Nummer 897, 18 Seiten
• ISSN Quelle: 2072-6694
• DOI: doi:10.3390/cancers12102897
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG)
• Sach-SW: ⁶⁸Ga-labeled somatostatin analogues
• Sach-SW: Merkel cell carcinoma (MCC)
• Sach-SW: positron emission tomography/computed tomography (PET/CT)
• K10plus-PPN: 1740871839

Abstract

Merkel cell carcinoma (MCC) is a rare neuroendocrine skin malignancy usually arising as a nonspecific nodule on sun-exposed areas of the head and neck. Given the poor prognosis of this aggressive tumor, assessment of disease burden in pre- and post-treatment care may ensure an optimal management with significant implications for patient surveillance and prognosis. Although imaging has established its role in locally advanced or distant metastatic MCC, a standard imaging algorithm is yet to be determined and respective recommendations are mainly based on melanoma. Positron emission tomography/computed tomography (PET/CT) is increasingly evolving as a valuable imaging tool in metastatic or unresectable MCC, mostly utilizing the glucose analogue 18F-fluorodeoxyglucose (18F-FDG) as a radiotracer. Despite being inferior in detecting the disease in its early stages compared to the “gold standard” of sentinel lymph node biopsy, recent evidence suggests an important role for 18F-FDG PET/CT in the routine workup of localized MCC. Moreover, 68Ga-labeled somatostatin analogues have been employed as PET tracers in the field of MCC with promising, yet comparable to 18F-FDG, results. This article provides a structured literature review of the most important studies investigating the role of PET or PET/CT in the clinical practice of MCC.