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Status: Bibliographieeintrag

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Verfasst von:Billing, Heiko [VerfasserIn]   i
 Burmeister, Greta [VerfasserIn]   i
 Plotnicki, Lukasz [VerfasserIn]   i
 Ahlenstiel, Thurid [VerfasserIn]   i
 Fichtner, Alexander [VerfasserIn]   i
 Sander, Anja [VerfasserIn]   i
 Höcker, Britta [VerfasserIn]   i
 Tönshoff, Burkhard [VerfasserIn]   i
 Pape, Lars [VerfasserIn]   i
Titel:Longitudinal growth on an everolimus- versus an MMF-based steroid-free immunosuppressive regimen in paediatric renal transplant recipients
Verf.angabe:Heiko Billing, Greta Burmeister, Lukasz Plotnicki, Thurid Ahlenstiel, Alexander Fichtner, Anja Sander, Britta Höcker, Burkhard Tönshoff and Lars Pape
E-Jahr:2013
Jahr:19 July 2013
Umfang:7 S.
Fussnoten:Gesehen am 25.11.2020
Titel Quelle:Enthalten in: Transplant international
Ort Quelle:Lausanne : Frontiers Media, 1988
Jahr Quelle:2013
Band/Heft Quelle:26(2013), 9, Seite 903-909
ISSN Quelle:1432-2277
Abstract:Concerns have been raised that mammalian target of rapamycin inhibitors in pediatric transplant recipients might interfere with longitudinal bone growth by inhibition of growth factor signaling and growth plate chondrocyte proliferation. We therefore undertook a prospective nested, case-control study on longitudinal growth over 2 years in steroid-free pediatric renal transplant recipients. Fourteen patients on a steroid-free maintenance immunosuppressive regimen consisting of low-dose everolimus (EVR) in conjunction with low-dose cyclosporine (CsA) were compared to a matched cohort of 14 steroid-free patients on a standard dose mycophenolate mofetil (MMF) regimen in conjunction with a standard dose calcineurin inhibitor (CNI). The mean change in height standard deviation (SD) score in the first study year was 0.31 ± 0.71 SD score in the EVR group compared to 0.31 ± 0.64 SD score in the MMF group (P = 0.20). For the entire study period of 2 years, the change in height SD score in the EVR group was 0.43 ± 0.81 SDS compared to 0.75 ± 0.85 SDS in the MMF group (P = 0.32). The percentage of prepubertal patients experiencing catch-up growth, defined as an increase in height SD score ≥0.5 in 2 years, was similar in the EVR group (5/8, 65%) and the MMF group (6/8, 75%; P = 1.00). Longitudinal growth over 2 years in steroid-free pediatric patients on low-dose EVR and CsA is not different to that of a matched steroid-free control group on an immunosuppressive regimen with standard-dose CNI and MMF. Hence, low-dose EVR does not appear to negatively impact short-term growth in pediatric renal transplant recipients.
DOI:doi:10.1111/tri.12148
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/https://doi.org/10.1111/tri.12148
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/tri.12148
 DOI: https://doi.org/10.1111/tri.12148
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:children and adolescents
 everolimus
 longitudinal growth
 mycophenolate mofetil
 renal transplantation
K10plus-PPN:1741024323
Verknüpfungen:→ Zeitschrift

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