Synthetic estrogens-mediated activation of JNK intracellular signaling molecule

• Verfasst von: Prifti, Sophia [VerfasserIn]
• Verfasst von: Mall, Petra [VerfasserIn]
• Verfasst von: Strowitzki, Thomas [VerfasserIn]
• Verfasst von: Rabe, Thomas [VerfasserIn]
• Titel: Synthetic estrogens-mediated activation of JNK intracellular signaling molecule
• Verf.angabe: S. Prifti, P. Mall, T. Strowitzki and T. Rabe
• Jahr: 2009
• Jahr des Originals: 2001
• Umfang: 7 S.
• Fussnoten: Published online: 28 Aug 2009 ; Gesehen am 25.11.2020
• Titel Quelle: Enthalten in: Gynecological endocrinology
• Ort Quelle: Abingdon, Oxon : Routledge, Taylor & Francis, 1987
• Jahr Quelle: 2001
• Band/Heft Quelle: 15(2001), 2, Seite 135-141
• ISSN Quelle: 1473-0766
• DOI: doi:10.1080/gye.15.2.135.141
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Breast cancer cells
• Sach-SW: Intracellular signaling
• Sach-SW: JNK
• Sach-SW: Western blot
• K10plus-PPN: 174103504X

Abstract

Signal transduction pathways regulate the transmission of specific signals to the cells from the surface to the nucleus. Activation of protein kinases such as JNKs (c-jun amino-terminal kinase), a subgroup of the mitogen activated protein kinase (MAPK) family, results in regulation of important cellular functions like cell growth and differentiation. The involvement of estrogens in stimulation of growth of already transformed breast cancer cells in vivo and in vitro accompanied with activation of JNKs prompted us to investigate the role of synthetic estrogens in the regulation of JNK expression...