| |  Online-Ressource |
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| Verfasst von: | Gerhardt, Axel [VerfasserIn]  |
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| | Usener, Dirk [VerfasserIn] |
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| | Keese, Michael [VerfasserIn] |
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| | Sturm, Jörg [VerfasserIn] |
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| | Schadendorf, Dirk [VerfasserIn] |
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| | Eichmüller, Stefan B. [VerfasserIn] |
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| Titel: | Tissue expression and sero-reactivity of tumor-specific antigens in colorectal cancer |
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| Verf.angabe: | Axel Gerhardt, Dirk Usener, Michael Keese, Jörg Sturm, Dirk Schadendorf, Stefan Eichmüller |
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| E-Jahr: | 2004 |
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| Jahr: | 24 January 2004 |
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| Umfang: | 10 S. |
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| Fussnoten: | Gesehen am 25.11.2020 |
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| Titel Quelle: | Enthalten in: Cancer letters |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1975 |
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| Jahr Quelle: | 2004 |
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| Band/Heft Quelle: | 208(2004), 2, Seite 197-206 |
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| ISSN Quelle: | 1872-7980 |
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| Abstract: | The expression of 14 individual and two groups of tumor antigens was characterized for colorectal carcinoma by RT-PCR using 26 colorectal carcinoma specimens, eight cell lines, six samples of patients with inflammatory bowl diseases, and nine specimens from different locations of an individual patient with a metastasized rectal carcinoma. The most frequently detected mRNAs were MAGE-A1 (58%), GAGE-3-7 (54%), and cTAGE-5a (31%). At medium frequencies (12-19%) we found cTAGE-1, MAGE-A2, se57-1, RAGE-4, and GAGE-1,2,8, while other tumor antigens were expressed rarely (<9%). 85% of the samples were positive for at least one of the most frequently expressed antigens. Using a secondary SEREX approach and sera of eight colorectal cancer patients we found reactive antibodies against recombinant cTAGE-1 (2 sera), se57-1 (2), truncated GAGE (1), and MAGE-A1 (1). We conclude that certain cancer-germline genes can be detected in colorectal cancer and might therefore be promising targets for immunotherapy. |
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| DOI: | doi:10.1016/j.canlet.2003.11.021 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.canlet.2003.11.021 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S0304383503008115 |
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| | DOI: https://doi.org/10.1016/j.canlet.2003.11.021 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cancer-germline genes |
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| | cTAGE |
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| | GAGE |
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| | MAGE |
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| | NY-ESO-1 |
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| K10plus-PPN: | 1741075912 |
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| Verknüpfungen: | → Zeitschrift |
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Tissue expression and sero-reactivity of tumor-specific antigens in colorectal cancer / Gerhardt, Axel [VerfasserIn]; 24 January 2004 (Online-Ressource)
