| |  Online-Ressource |
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| Verfasst von: | Toberer, Ferdinand [VerfasserIn]  |
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| | Hänßle, Holger [VerfasserIn] |
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| | Laimer, Martin [VerfasserIn] |
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| | Heinzel-Gutenbrunner, Monika [VerfasserIn] |
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| | Enk, Alexander [VerfasserIn] |
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| | Hartschuh, Wolfgang [VerfasserIn] |
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| | Helmbold, Peter [VerfasserIn] |
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| | Kutzner, Heinz [VerfasserIn] |
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| Titel: | Vascular endothelial growth factor receptor-3 expression predicts sentinel node status in primary cutaneous melanoma |
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| Verf.angabe: | Ferdinand Toberer, Holger A. Haenssle, Martin Laimer, Monika Heinzel-Gutenbrunner, Alexander Enk, Wolfgang Hartschuh, Peter Helmbold and Heinz Kutzner |
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| E-Jahr: | 2020 |
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| Jahr: | July 3, 2020 |
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| Umfang: | 6 S. |
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| Fussnoten: | Gesehen am 26.11.2020 |
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| Titel Quelle: | Enthalten in: Acta dermato-venereologica |
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| Ort Quelle: | Uppsala : Acta Dermato-Venereologica, 1946 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 100(2020) Artikel-Nummer adv00235, 6 Seiten |
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| ISSN Quelle: | 1651-2057 |
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| Abstract: | This study analysed the expression of vascular endothelial growth factor-A (VEGF), VEGFR-2, and VEGFR-3 in primary cutaneous melanomas with positive and negative sentinel node status (SLN) (a total of 58 specimens divided into 2 groups of 29 for each status). The specimens were collected from the pathological archive of the department of Dermatology, Venereology and Allergology of the University Medical Center Heidelberg. A quantification score was developed for protein expression, by considering the percentage of positive melanoma cells (0: 0%, 1: up to 1%, 2: 2-10%, 3: 11-50%, and 4: 50%) in relation to the intensity of staining (0: negative, 1: low, 2: medium, 3: strong). Tumoural VEGFR-3 expression (mean +/- standard deviation) in SLN+ tumours (9.62 +/- 3.09) was significantly stronger than in SLN- tumours (6.13 +/- 3.87; p < 0.001). A binary logistic regression model proved VEGFR-3 expression and tumour thickness to be significant independent predictors of SLN. These data provide evidence that VEGFR-3 expression may play a critical role in the pathogenesis of malignant melanoma and that its investigation may help to improve the selection of patients with primary cutaneous melanoma for sentinel node biopsy. |
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| DOI: | doi:10.2340/00015555-3588 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.2340/00015555-3588 |
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| | Volltext: https://www.medicaljournals.se/acta/content/abstract/10.2340/00015555-3588 |
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| | DOI: https://doi.org/10.2340/00015555-3588 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | angiogenesis |
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| | biopsy |
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| | marker |
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| | melanoma |
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| | metastasis |
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| | microvessel density |
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| | normal epidermis |
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| | progression |
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| | sentinel node biopsy |
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| | stage |
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| | tumors |
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| | vegf |
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| | vegfr-2 |
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| | vegfr-3 |
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| K10plus-PPN: | 1741165660 |
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| Verknüpfungen: | → Zeitschrift |
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Vascular endothelial growth factor receptor-3 expression predicts sentinel node status in primary cutaneous melanoma / Toberer, Ferdinand [VerfasserIn]; July 3, 2020 (Online-Ressource)
