Serum soluble receptor for advanced glycation end products (sRAGE) is independently associated with cigarette smoking in non-diabetic healthy subjects

• Verfasst von: Biswas, Subrata Kumar [VerfasserIn]
• Verfasst von: Mudi, Sonchita R [VerfasserIn]
• Verfasst von: Mollah, Forhadul H [VerfasserIn]
• Verfasst von: Bierhaus, Angelika [VerfasserIn]
• Verfasst von: Arslan, M Iqbal [VerfasserIn]
• Titel: Serum soluble receptor for advanced glycation end products (sRAGE) is independently associated with cigarette smoking in non-diabetic healthy subjects
• Verf.angabe: Subrata K Biswas, Sonchita R Mudi, Forhadul H Mollah, Angelika Bierhaus and M Iqbal Arslan
• E-Jahr: 2013
• Jahr: March 21, 2013
• Umfang: 3 S.
• Teil: volume:10
• Teil: year:2013
• Teil: number:4
• Teil: pages:380-382
• Teil: extent:3
• Fussnoten: Gesehen am 26.11.2020
• Titel Quelle: Enthalten in: Diabetes & vascular disease research
• Ort Quelle: London : Sage, 2004
• Jahr Quelle: 2013
• Band/Heft Quelle: 10(2013), 4, Seite 380-382
• ISSN Quelle: 1752-8984
• DOI: doi:10.1177/1479164113479618
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1741199565

Abstract

This study was designed to explore the relationship between serum levels of soluble receptor for advanced glycation end products (sRAGE) and cigarette smoking in non-diabetic healthy subjects. A total of 98 non-diabetic, otherwise healthy male subjects were recruited. A fasting blood sample and medical history including detail history of cigarette smoking was collected. The serum sRAGE levels were found significantly higher (p=0.002) in cigarette smokers (1475±422 pg/ml, n=45) compared with non-smokers (1165±350 pg/ml, n=53). Moreover, among the cigarette smokers, serum sRAGE levels were found significantly correlated with number of cigarettes smoked per day (r=0.60, p<0.001). In bivariate analysis in the total population, sRAGE positively correlated with smoking habit (r=0.37, p=0.002) and negatively correlated with systolic (r=-0.32, p=0.01) and diastolic blood pressure (r=-0.36, p=0.003). However, in stepwise multivariate linear regression model, sRAGE showed a significant independent association with smoking habit (b=0.32, p=0.007, R2=0.23). In conclusion, this study for the first time shows a significant elevation of serum sRAGE in cigarette smokers compared with non-smokers, a strong correlation between sRAGE and number of cigarettes smoked per day and an independent association of sRAGE with smoking habit in non-diabetic healthy subjects.