| |  Online-Ressource |
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| Verfasst von: | Blaising, Julie [VerfasserIn]  |
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| | Lévy, Pierre L. [VerfasserIn] |
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| | Polyak, Stephen J. [VerfasserIn] |
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| | Stanifer, Megan [VerfasserIn] |
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| | Boulant, Steeve [VerfasserIn] |
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| | Pécheur, Eve-Isabelle [VerfasserIn] |
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| Titel: | Arbidol inhibits viral entry by interfering with clathrin-dependent trafficking |
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| Verf.angabe: | Julie Blaising, Pierre L. Lévy, Stephen J. Polyak, Megan Stanifer, Steeve Boulant, Eve-Isabelle Pécheur |
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| E-Jahr: | 2013 |
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| Jahr: | 25 August 2013 |
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| Umfang: | 5 S. |
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| Fussnoten: | Gesehen am 26.11.2020 |
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| Titel Quelle: | Enthalten in: Antiviral research |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1981 |
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| Jahr Quelle: | 2013 |
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| Band/Heft Quelle: | 100(2013), 1, Seite 215-219 |
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| ISSN Quelle: | 1872-9096 |
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| Abstract: | Arbidol (ARB) is a broad-spectrum antiviral displaying activity against a number of enveloped and non-enveloped viruses. It was described as a viral entry inhibitor and shown to interact at the molecular level with lipid membranes and viral fusion glycoproteins to impede viral entry and fusion. However its mechanism of action at the cellular level remains unknown. Here, by using live-cell confocal imaging and the hepatitis C virus as a model virus, we show that ARB affects clathrin-mediated endocytosis by impeding dynamin-2-induced membrane scission. Moreover it induces the intracellular accumulation of clathrin-coated structures where viral particles are trapped. Collectively, our results shed light on the mechanistic aspects of ARB antiviral activity and suggest that ARB could prevent cell infection by viruses that enter through clathrin-mediated endocytosis. |
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| DOI: | doi:10.1016/j.antiviral.2013.08.008 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.antiviral.2013.08.008 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S0166354213002167 |
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| | DOI: https://doi.org/10.1016/j.antiviral.2013.08.008 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Arbidol |
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| | Broad spectrum antiviral |
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| | Entry |
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| | Hepatitis C virus |
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| | Reovirus |
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| | Vesicular stomatitis virus |
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| K10plus-PPN: | 1741215358 |
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| Verknüpfungen: | → Zeitschrift |
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Arbidol inhibits viral entry by interfering with clathrin-dependent trafficking / Blaising, Julie [VerfasserIn]; 25 August 2013 (Online-Ressource)
