| Online-Ressource |
Verfasst von: | Boehm, Dorothee [VerfasserIn]  |
| Arras, Denise [VerfasserIn]  |
| Schröder, Christina [VerfasserIn]  |
| Siemers, Frank [VerfasserIn]  |
| Corterier, C. C. [VerfasserIn]  |
| Lehnhardt, Marcus [VerfasserIn]  |
| Dadras, Mehran [VerfasserIn]  |
| Hartmann, Bernd [VerfasserIn]  |
| Kuepper, Simon [VerfasserIn]  |
| Czaja, Kay-Uwe [VerfasserIn]  |
| Kneser, Ulrich [VerfasserIn]  |
| Hirche, Christoph [VerfasserIn]  |
Titel: | Mechanical ventilation as a surrogate for diagnosing the onset of abdominal compartment syndrome (ACS) in severely burned patients (TIRIFIC-study Part II) |
Verf.angabe: | Dorothee Boehm, Denise Arras, Christina Schroeder, Frank Siemers, C.C. Corterier, Marcus Lehnhardt, Mehran Dadras, Bernd Hartmann, Simon Kuepper, Kay-Uwe Czaja, Ulrich Kneser, Christoph Hirche |
E-Jahr: | 2020 |
Jahr: | Sep 2020 |
Umfang: | 8 S. |
Fussnoten: | Gesehen am 26.11.2020 |
Titel Quelle: | Enthalten in: Burns |
Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1974 |
Jahr Quelle: | 2020 |
Band/Heft Quelle: | 46(2020), 6, Seite 1320-1327 |
ISSN Quelle: | 1879-1409 |
Abstract: | Intra-abdominal compartment syndrome (ACS) is a devastating complication in burn patients with a high mortality. Apart from high-volume resuscitation as known risk factor, also mechanical ventilation seems to influence the development of ACS. The TIRIFIC trial is a retrospective, matched-pair analysis. Thirty-eight burn patients with ACS were matched for burned total body surface area (TBSA), age and mechanical ventilation (MV). In contrast to the already published part I addressing fluid resuscitation as a risk factor, the parameters analyzed in part II were maximum and average PEEP and peak pressure levels as well as serum lactate levels and prokinetic therapy. For subgroup-analysis the ACS-group was split up into an early-onset and late-onset ACS-group according to the median time between burn trauma and ACS. The groups were analyzed with a two-sided Mann-Whitney-U-test with significance set at p < 0.05. In the ACS-group all ventilation pressures (maximum and average PEEP and peak pressure levels) were significantly increased compared to control. The subgroup-analysis showed significantly increased maximum PEEP and peak pressure levels in early- and late-onset ACS-groups versus control. However, the average ventilation pressure levels were only increased in the early-onset ACS-group (average PEEP p = 0.0069; average peak pressure p = 0.05). The TIRIFIC trial showed significantly increased ventilation pressures in the ACS group in general as a surrogate parameter to support early diagnostics. Especially, maximum PEEP levels and peak pressures are significantly increased in both, early- and late-onset ACS. As an addition to the actual WSACS guidelines we suggest IAP measurement in mechanically ventilated burn patients if ventilating pressures are rising continuously without a clear pulmonary or otherwise identifiable reason. (C) 2020 Elsevier Ltd and ISBI. All rights reserved. |
DOI: | doi:10.1016/j.burns.2020.02.005 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.burns.2020.02.005 |
| DOI: https://doi.org/10.1016/j.burns.2020.02.005 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | acs |
| Burn |
| Influencing factor |
| Intra-abdominal compartment syndrome |
| intraabdominal hypertension |
| Mechanical ventilation |
| pressure |
| resuscitation |
| Surrogate |
| WSACS guidelines |
K10plus-PPN: | 1741230675 |
Verknüpfungen: | → Zeitschrift |
Mechanical ventilation as a surrogate for diagnosing the onset of abdominal compartment syndrome (ACS) in severely burned patients (TIRIFIC-study Part II) / Boehm, Dorothee [VerfasserIn]; Sep 2020 (Online-Ressource)