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Status: Bibliographieeintrag

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Verfasst von:Boehm, Dorothee [VerfasserIn]   i
 Arras, Denise [VerfasserIn]   i
 Schröder, Christina [VerfasserIn]   i
 Siemers, Frank [VerfasserIn]   i
 Corterier, C. C. [VerfasserIn]   i
 Lehnhardt, Marcus [VerfasserIn]   i
 Dadras, Mehran [VerfasserIn]   i
 Hartmann, Bernd [VerfasserIn]   i
 Kuepper, Simon [VerfasserIn]   i
 Czaja, Kay-Uwe [VerfasserIn]   i
 Kneser, Ulrich [VerfasserIn]   i
 Hirche, Christoph [VerfasserIn]   i
Titel:Mechanical ventilation as a surrogate for diagnosing the onset of abdominal compartment syndrome (ACS) in severely burned patients (TIRIFIC-study Part II)
Verf.angabe:Dorothee Boehm, Denise Arras, Christina Schroeder, Frank Siemers, C.C. Corterier, Marcus Lehnhardt, Mehran Dadras, Bernd Hartmann, Simon Kuepper, Kay-Uwe Czaja, Ulrich Kneser, Christoph Hirche
E-Jahr:2020
Jahr:Sep 2020
Umfang:8 S.
Fussnoten:Gesehen am 26.11.2020
Titel Quelle:Enthalten in: Burns
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1974
Jahr Quelle:2020
Band/Heft Quelle:46(2020), 6, Seite 1320-1327
ISSN Quelle:1879-1409
Abstract:Intra-abdominal compartment syndrome (ACS) is a devastating complication in burn patients with a high mortality. Apart from high-volume resuscitation as known risk factor, also mechanical ventilation seems to influence the development of ACS. The TIRIFIC trial is a retrospective, matched-pair analysis. Thirty-eight burn patients with ACS were matched for burned total body surface area (TBSA), age and mechanical ventilation (MV). In contrast to the already published part I addressing fluid resuscitation as a risk factor, the parameters analyzed in part II were maximum and average PEEP and peak pressure levels as well as serum lactate levels and prokinetic therapy. For subgroup-analysis the ACS-group was split up into an early-onset and late-onset ACS-group according to the median time between burn trauma and ACS. The groups were analyzed with a two-sided Mann-Whitney-U-test with significance set at p < 0.05. In the ACS-group all ventilation pressures (maximum and average PEEP and peak pressure levels) were significantly increased compared to control. The subgroup-analysis showed significantly increased maximum PEEP and peak pressure levels in early- and late-onset ACS-groups versus control. However, the average ventilation pressure levels were only increased in the early-onset ACS-group (average PEEP p = 0.0069; average peak pressure p = 0.05). The TIRIFIC trial showed significantly increased ventilation pressures in the ACS group in general as a surrogate parameter to support early diagnostics. Especially, maximum PEEP levels and peak pressures are significantly increased in both, early- and late-onset ACS. As an addition to the actual WSACS guidelines we suggest IAP measurement in mechanically ventilated burn patients if ventilating pressures are rising continuously without a clear pulmonary or otherwise identifiable reason. (C) 2020 Elsevier Ltd and ISBI. All rights reserved.
DOI:doi:10.1016/j.burns.2020.02.005
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.burns.2020.02.005
 DOI: https://doi.org/10.1016/j.burns.2020.02.005
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:acs
 Burn
 Influencing factor
 Intra-abdominal compartment syndrome
 intraabdominal hypertension
 Mechanical ventilation
 pressure
 resuscitation
 Surrogate
 WSACS guidelines
K10plus-PPN:1741230675
Verknüpfungen:→ Zeitschrift

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