Megadalton chromatin remodelers

• Verfasst von: Jungblut, Anna [VerfasserIn]
• Verfasst von: Hopfner, Karl-Peter [VerfasserIn]
• Verfasst von: Eustermann, Sebastian [VerfasserIn]
• Titel: Megadalton chromatin remodelers
• Titelzusatz: common principles for versatile functions
• Verf.angabe: Anna Jungblut, Karl-Peter Hopfner and Sebastian Eustermann
• E-Jahr: 2020
• Jahr: 6 August 2020
• Umfang: 11 S.
• Fussnoten: Gesehen am 27.11.2020
• Titel Quelle: Enthalten in: Current opinion in structural biology
• Ort Quelle: Amsterdam [u.a.] : Elsevier, 1991
• Jahr Quelle: 2020
• Band/Heft Quelle: 64(2020), Seite 134-144
• DOI: doi:10.1016/j.sbi.2020.06.024
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1741288789

Abstract

ATP-dependent chromatin remodelers are enigmatic macromolecular machines that govern the arrangement and composition of nucleosomes across eukaryotic genomes. Here, we review the recent breakthrough provided by cryo-electron microscopy that reveal the first high-resolution insights into all four families of remodelers. We highlight the emerging structural and mechanistic principles with a particular focus on multi-subunit SWI/SNF and INO80/SWR1 complexes. A conserved architecture comprising a motor, rotor, stator and grip suggests a unifying mechanism for how stepwise DNA translocation enables large scale reconfigurations of nucleosomes. A molecular circuitry involving the nuclear actin containing module establishes a framework for understanding allosteric regulation. Remodelers emerge as programable hubs that enable differential processing of genetic and epigenetic information in response to the physiological state of a cell.