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| Verfasst von: | Cardoso-Moreira, Margarida [VerfasserIn]  |
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| | Sarropoulos, Ioannis [VerfasserIn] |
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| | Velten, Britta [VerfasserIn] |
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| | Mort, Matthew [VerfasserIn] |
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| | Cooper, David N. [VerfasserIn] |
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| | Huber, Wolfgang [VerfasserIn] |
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| | Kaessmann, Henrik [VerfasserIn] |
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| Titel: | Developmental gene expression differences between humans and mammalian models |
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| Verf.angabe: | Margarida Cardoso-Moreira, Ioannis Sarropoulos, Britta Velten, Matthew Mort, David N. Cooper, Wolfgang Huber, and Henrik Kaessmann |
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| E-Jahr: | 2020 |
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| Jahr: | October 27, 2020 |
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| Umfang: | 17 S. |
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| Fussnoten: | Gesehen am 27.11.2020 |
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| Titel Quelle: | Enthalten in: Cell reports |
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| Ort Quelle: | Maryland Heights, MO : Cell Press, 2012 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 33(2020,4) Artikel-Nummer 108308, 17 Seiten |
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| ISSN Quelle: | 2211-1247 |
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| Abstract: | Identifying the molecular programs underlying human organ development and how they differ from model species is key for understanding human health and disease. Developmental gene expression profiles provide a window into the genes underlying organ development and a direct means to compare them across species. We use a transcriptomic resource covering the development of seven organs to characterize the temporal profiles of human genes associated with distinct disease classes and to determine, for each human gene, the similarity of its spatiotemporal expression with its orthologs in rhesus macaque, mouse, rat, and rabbit. We find clear associations between spatiotemporal profiles and the phenotypic manifestations of diseases. We also find that half of human genes differ from their mouse orthologs in their temporal trajectories in at least one of the organs. These include more than 200 genes associated with brain, heart, and liver disease for which mouse models should undergo extra scrutiny. |
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| DOI: | doi:10.1016/j.celrep.2020.108308 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.celrep.2020.108308 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S2211124720312973 |
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| | DOI: https://doi.org/10.1016/j.celrep.2020.108308 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | animal models |
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| | comparative transcriptomics |
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| | development |
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| | gene expression |
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| | human disease |
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| | organogenesis |
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| K10plus-PPN: | 1741292999 |
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| Verknüpfungen: | → Zeitschrift |
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Developmental gene expression differences between humans and mammalian models / Cardoso-Moreira, Margarida [VerfasserIn]; October 27, 2020 (Online-Ressource)
