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| Verfasst von: | Di Marco, Barbara [VerfasserIn]  |
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| | Crouch, Elizabeth E. [VerfasserIn] |
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| | Shah, Bhavin [VerfasserIn] |
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| | Duman, Aset Ceren [VerfasserIn] |
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| | Paredes, Mercedes F. [VerfasserIn] |
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| | Ruiz de Almodóvar, Carmen [VerfasserIn] |
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| | Huang, Eric J. [VerfasserIn] |
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| | Alfonso, Julieta [VerfasserIn] |
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| Titel: | Reciprocal interaction between vascular filopodia and neural stem cells shapes neurogenesis in the ventral telencephalon |
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| Verf.angabe: | Barbara Di Marco, Elizabeth E. Crouch, Bhavin Shah, Ceren Duman, Mercedes F. Paredes, Carmen Ruiz de Almodovar, Eric J. Huang, and Julieta Alfonso |
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| E-Jahr: | 2020 |
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| Jahr: | October 13, 2020 |
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| Umfang: | 22 S. |
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| Fussnoten: | Gesehen am 30.11.2020 |
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| Titel Quelle: | Enthalten in: Cell reports |
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| Ort Quelle: | Maryland Heights, MO : Cell Press, 2012 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 33(2020,2) Artikel-Nummer 108256, 22 Seiten |
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| ISSN Quelle: | 2211-1247 |
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| Abstract: | Angiogenesis and neurogenesis are tightly coupled during embryonic brain development. However, little is known about how these two processes interact. We show that nascent blood vessels actively contact dividing neural stem cells by endothelial filopodia in the ventricular zone (VZ) of the murine ventral telencephalon; this association is conserved in the human ventral VZ. Using mouse mutants with altered vascular filopodia density, we show that this interaction leads to prolonged cell cycle of apical neural progenitors (ANPs) and favors early neuronal differentiation. Interestingly, pharmacological experiments reveal that ANPs induce vascular filopodia formation by upregulating vascular endothelial growth factor (VEGF)-A in a cell-cycle-dependent manner. This mutual relationship between vascular filopodia and ANPs works as a self-regulatory system that senses ANP proliferation rates and rapidly adjusts neuronal production levels. Our findings indicate a function of vascular filopodia in fine-tuning neural stem cell behavior, which is the basis for proper brain development. |
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| DOI: | doi:10.1016/j.celrep.2020.108256 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.celrep.2020.108256 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S2211124720312456 |
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| | DOI: https://doi.org/10.1016/j.celrep.2020.108256 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | angiogenesis |
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| | cell cycle |
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| | development |
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| | ganglionic eminence |
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| | human prenatal brain |
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| | neural stem cells |
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| | neurovascular interaction |
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| | RBPJ |
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| | S1P1 |
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| | VEGF |
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| K10plus-PPN: | 1741484847 |
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| Verknüpfungen: | → Zeitschrift |
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Reciprocal interaction between vascular filopodia and neural stem cells shapes neurogenesis in the ventral telencephalon / Di Marco, Barbara [VerfasserIn]; October 13, 2020 (Online-Ressource)
