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| Verfasst von: | Rangrez, Ashraf Yusuf [VerfasserIn]  |
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| | Borlepawar, Ankush [VerfasserIn] |
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| | Schmiedel, Nesrin [VerfasserIn] |
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| | Deshpande, Anushka [VerfasserIn] |
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| | Remes, Anca [VerfasserIn] |
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| | Kumari, Manju [VerfasserIn] |
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| | Bernt, Alexander [VerfasserIn] |
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| | Christen, Lynn [VerfasserIn] |
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| | Helbig, Andreas [VerfasserIn] |
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| | Jungmann, Andreas [VerfasserIn] |
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| | Sossalla, Samuel [VerfasserIn] |
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| | Tholey, Andreas [VerfasserIn] |
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| | Müller, Oliver J. [VerfasserIn] |
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| | Frank, Derk [VerfasserIn] |
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| | Frey, Norbert [VerfasserIn] |
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| Titel: | The E3 ubiquitin ligase HectD3 attenuates cardiac hypertrophy and inflammation in mice |
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| Verf.angabe: | Ashraf Yusuf Rangrez, Ankush Borlepawar, Nesrin Schmiedel, Anushka Deshpande, Anca Remes, Manju Kumari, Alexander Bernt, Lynn Christen, Andreas Helbig, Andreas Jungmann, Samuel Sossalla, Andreas Tholey, Oliver J. Müller, Derk Frank & Norbert Frey |
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| E-Jahr: | 2020 |
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| Jahr: | 09 October 2020 |
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| Umfang: | 15 S. |
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| Fussnoten: | Gesehen am 02.12.2020 |
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| Titel Quelle: | Enthalten in: Communications biology |
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| Ort Quelle: | London : Springer Nature, 2018 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 3(2020), Artikel-ID 562, Seite 1-15 |
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| ISSN Quelle: | 2399-3642 |
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| Abstract: | Myocardial inflammation has recently been recognized as a distinct feature of cardiac hypertrophy and heart failure. HectD3, a HECT domain containing E3 ubiquitin ligase has previously been investigated in the host defense against infections as well as neuroinflammation; its cardiac function however is still unknown. Here we show that HectD3 simultaneously attenuates Calcineurin-NFAT driven cardiomyocyte hypertrophy and the pro-inflammatory actions of LPS/interferon-γ via its cardiac substrates SUMO2 and Stat1, respectively. AAV9-mediated overexpression of HectD3 in mice in vivo not only reduced cardiac SUMO2/Stat1 levels and pathological hypertrophy but also largely abolished macrophage infiltration and fibrosis induced by pressure overload. Taken together, we describe a novel cardioprotective mechanism involving the ubiquitin ligase HectD3, which links anti-hypertrophic and anti-inflammatory effects via dual regulation of SUMO2 and Stat1. In a broader perspective, these findings support the notion that cardiomyocyte growth and inflammation are more intertwined than previously anticipated. |
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| DOI: | doi:10.1038/s42003-020-01289-2 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/s42003-020-01289-2 |
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| | Volltext: https://www.nature.com/articles/s42003-020-01289-2 |
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| | DOI: https://doi.org/10.1038/s42003-020-01289-2 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1741687306 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ E3 ubiquitin ligase HectD3 attenuates cardiac hypertrophy and inflammation in mice / Rangrez, Ashraf Yusuf [VerfasserIn]; 09 October 2020 (Online-Ressource)
