| |  Online-Ressource |
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| Verfasst von: | Arians, Nathalie [VerfasserIn]  |
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| | Oelmann-Avendano, Jan Tobias [VerfasserIn] |
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| | Schmitt, Daniela [VerfasserIn] |
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| | Meixner, Eva [VerfasserIn] |
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| | Wark, Antje [VerfasserIn] |
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| | Hörner-Rieber, Juliane [VerfasserIn] |
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| | El-Shafie, Rami [VerfasserIn] |
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| | Lang, Kristin [VerfasserIn] |
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| | Wallwiener, Markus [VerfasserIn] |
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| | Debus, Jürgen [VerfasserIn] |
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| Titel: | Evaluation of uterine brachytherapy as primary treatment option for elderly patients with medically inoperable endometrial cancer |
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| Titelzusatz: | a single-center experience and review of the literature |
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| Verf.angabe: | Nathalie Arians, Jan Tobias Oelmann-Avendano, Daniela Schmitt, Eva Meixner, Antje Wark, Juliane Hoerner-Rieber, Rami A. El Shafie, Kristin Lang, Markus Wallwiener and Jürgen Debus |
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| E-Jahr: | 2020 |
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| Jahr: | 15 August 2020 |
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| Umfang: | 13 S. |
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| Fussnoten: | Gesehen am 03.12.2020 |
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| Titel Quelle: | Enthalten in: Cancers |
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| Ort Quelle: | Basel : MDPI, 2009 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 12(2020,8) Artikel-Nummer 2301, 13 Seiten |
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| ISSN Quelle: | 2072-6694 |
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| Abstract: | We aimed to gain more evidence regarding the feasibility, toxicity, and oncological outcome of primary brachytherapy in patients with medically inoperable endometrial cancer. Thirteen patients receiving primary brachytherapy ± external beam radiotherapy (EBRT) for endometrial cancer due to medical inoperability were identified. The Kaplan–Meier method was used to estimate overall survival (OS), progression-free survival (PFS), and local failure-free survival (LFFS). Univariate outcome analyses were performed using the log-rank test. Peri-interventional complications, acute and chronic toxicities were evaluated. Additionally, we performed a Pubmed search and review of the literature of the last 10 years. Mean age at time of diagnosis was 73.9 years (60.4–87.1 years). Eleven patients were staged FIGO IA/B and one patient each with FIGO IIIA and IIIC. Kaplan–Meier-estimated 2-/5-year LFFS were 76.2%/56.4%, respectively. High grading correlated with a worse LFFS (p = 0.069). Kaplan–Meier-estimated 2-/5-year PFS were 76.9%/53.8% and 2-/5-year-OS were 76.9%/69.2%, respectively. No acute toxicities > grade II and only two late toxicities grade II/III occurred. We observed three peri-interventional complications. The available evidence suggests high rates of local control after definitive brachytherapy for inoperable endometrial cancer with a favorable toxicity profile. Definitive brachytherapy +/− EBRT should be considered as the preferred approach for this patient group. |
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| DOI: | doi:10.3390/cancers12082301 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.3390/cancers12082301 |
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| | Volltext: https://www.mdpi.com/2072-6694/12/8/2301 |
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| | DOI: https://doi.org/10.3390/cancers12082301 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | definitive radiotherapy |
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| | elderly patients |
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| | endometrial cancer |
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| | functional inoperability |
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| | intrauterine brachytherapy |
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| K10plus-PPN: | 1741925789 |
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| Verknüpfungen: | → Zeitschrift |
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Evaluation of uterine brachytherapy as primary treatment option for elderly patients with medically inoperable endometrial cancer / Arians, Nathalie [VerfasserIn]; 15 August 2020 (Online-Ressource)
