| Online-Ressource |
Verfasst von: | Heckmann, Markus B. [VerfasserIn]  |
| Reinhardt, Finn [VerfasserIn]  |
| Finke, Daniel [VerfasserIn]  |
| Katus, Hugo [VerfasserIn]  |
| Haberkorn, Uwe [VerfasserIn]  |
| Leuschner, Florian [VerfasserIn]  |
| Lehmann, Lorenz [VerfasserIn]  |
Titel: | Relationship between cardiac fibroblast activation protein activity by positron emission tomography and cardiovascular disease |
Verf.angabe: | Markus B. Heckmann, MD, Finn Reinhardt, Daniel Finke, MD, Hugo A. Katus, MD, Uwe Haberkorn, Florian Leuschner, MD, and Lorenz H. Lehmann, MD |
E-Jahr: | 2020 |
Jahr: | 11 Sep 2020 |
Fussnoten: | Gesehen am 04.12.2020 |
Titel Quelle: | Enthalten in: Circulation / Cardiovascular imaging |
Ort Quelle: | Philadelphia, Pa. : Lippincott, Williams & Wilkins, 2008 |
Jahr Quelle: | 2020 |
Band/Heft Quelle: | 13(2020), 9 |
ISSN Quelle: | 1942-0080 |
Abstract: | Background: FAP (fibroblast activation protein) plays an important role in cardiac wound healing and remodeling. Although initially developed as a theranostic ligand for metastasized cancer, FAPI (FAP inhibitor) tracers have recently been used to study cardiac remodeling following myocardial infarction in small-animal models. The aim of the study was to evaluate the activity of FAP via FAPI-positron emission tomography-computed tomography scans in human hearts. Methods: FAPI-positron emission tomography-computed tomography scans of 229 patients of 2 consecutive cohorts (modeling cohort: n=185; confirmatory cohort: n=44) suffering from metastasized cancer were analyzed applying the American Heart Association 17-segment model of the left ventricle. Logistic regression models were created using data from the modeling cohort. Multivariate regression models were established using Akaike information criterion in a step-down approach. Results: Fourteen percent of patients had preexisting coronary artery disease (n=31), 33% arterial hypertension (n=75), and 12% diabetes mellitus type II (n=28). Forty-three percent had been treated with platin derivatives (n=100), 14% with anthracyclines (n=32), and 10% had a history of prior radiation to the chest (n=23). High left ventricular FAPI signals correlated with the presence of cardiovascular risk factors (odds ratio [OR], 4.3,P=0.0029), a focal myocardial signal pattern (OR, 3.9,P=0.0068), diabetes mellitus type II (OR, 4.1,P=0.046), and beta-blocker use (OR, 3.8,P=0.049) in univariate regression models. In a multivariate analysis, increased signal intensity was significantly higher in patients with cardiovascular risk factors (overweight [OR, 2.6,P=0.023], diabetes mellitus type II [OR, 2.9,P=0.041], certain chemotherapies [platinum derivatives; OR, 3.0,P=0.034], and a history of radiation to the chest [OR, 3.5,P=0.024]). A focal enrichment pattern was more frequently observed in patients with known cardiovascular risk factors (P<0.0001). Conclusions: FAPI-positron emission tomography-computed tomography scans represent a new imaging modality to investigate cardiac FAP. High signal intensities correlate with cardiovascular risk factors and metabolic disease. |
DOI: | doi:10.1161/CIRCIMAGING.120.010628 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1161/CIRCIMAGING.120.010628 |
| DOI: https://doi.org/10.1161/CIRCIMAGING.120.010628 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | alpha |
| diabetes mellitus |
| fibroblast |
| myocardial infarction |
| risk factors |
| tomography |
K10plus-PPN: | 1742059031 |
Verknüpfungen: | → Zeitschrift |
Relationship between cardiac fibroblast activation protein activity by positron emission tomography and cardiovascular disease / Heckmann, Markus B. [VerfasserIn]; 11 Sep 2020 (Online-Ressource)