| Online-Ressource |
Verfasst von: | Butkiewicz, Dorota [VerfasserIn]  |
| Popanda, Odilia [VerfasserIn]  |
| Risch, Angela [VerfasserIn]  |
| Edler, Lutz [VerfasserIn]  |
| Dienemann, Hendrik [VerfasserIn]  |
| Schulz, Volker [VerfasserIn]  |
| Kayser, Klaus [VerfasserIn]  |
| Drings, Peter [VerfasserIn]  |
| Bartsch, Helmut [VerfasserIn]  |
| Schmezer, Peter [VerfasserIn]  |
Titel: | Association between the risk for lung adenocarcinoma and a (−4) G-to-A polymorphism in the XPA gene |
Verf.angabe: | Dorota Butkiewicz, Odilia Popanda, Angela Risch, Lutz Edler, Hendrik Dienemann, Volker Schulz, Klaus Kayser, Peter Drings, Helmut Bartsch, and Peter Schmezer |
E-Jahr: | 2004 |
Jahr: | December 2004 |
Umfang: | 6 S. |
Fussnoten: | Gesehen am 07.12.2020 |
Titel Quelle: | Enthalten in: Cancer epidemiology, biomarkers & prevention |
Ort Quelle: | Philadelphia, Pa. : AACR, 1991 |
Jahr Quelle: | 2004 |
Band/Heft Quelle: | 13(2004), 12, Seite 2242-2246 |
ISSN Quelle: | 1538-7755 |
Abstract: | Polymorphisms of genes coding for DNA repair can affect lung cancer risk. A common single nucleotide (−4) G-to-A polymorphism was identified previously in the 5′ untranslated region of the XPA gene. In a case-control study in European Caucasians, the influence of this polymorphism on primary lung cancer risk overall and according to histologic subtypes was investigated. Four hundred sixty-three lung cancer cases (including 204 adenocarcinoma and 212 squamous cell carcinoma) and 460 tumor-free hospital controls were investigated using PCR amplification and melting point analysis of sequence-specific hybridization probes. Odds ratios (OR) were calculated by multiple logistic regression analysis adjusting for age, gender, smoking habits, and occupational exposure and showed a slightly enhanced risk for all lung cancer cases as well as for squamous cell carcinoma and adenocarcinoma cases. Gene-environment interactions were analyzed with respect to smoking and occupational exposure. A nearly 3-fold increased risk for adenocarcinoma associated with the XPA AA genotype was observed for occupationally exposed individuals (OR, 2.95; 95% confidence interval, 1.42-6.14) and for heavy smokers (OR, 2.52; 95% confidence interval, 1.17-5.42). No genotype-dependent increase in OR was found for nonexposed individuals or those smoking <20 pack-years. The significant effect of the XPA polymorphism in heavy smokers and occupationally exposed individuals suggests an important gene-environment interaction for the XPA gene. The underlying mechanisms as to why AA homozygotes are predisposed to lung adenocarcinoma and which specific carcinogens are involved remains to be determined. |
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Volltext: https://cebp.aacrjournals.org/content/13/12/2242 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1742217001 |
Verknüpfungen: | → Zeitschrift |
Association between the risk for lung adenocarcinoma and a (−4) G-to-A polymorphism in the XPA gene / Butkiewicz, Dorota [VerfasserIn]; December 2004 (Online-Ressource)