| |  Online-Ressource |
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| Verfasst von: | Bertl, Elisabeth [VerfasserIn]  |
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| | Bartsch, Helmut [VerfasserIn] |
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| | Gerhäuser, Clarissa [VerfasserIn] |
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| Titel: | Inhibition of endothelial cell functions by novel potential cancer chemopreventive agents |
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| Verf.angabe: | Elisabeth Bertl, Hans Becker, Theophil Eicher, Christian Herhaus, Govind Kapadia, Helmut Bartsch, Clarissa Gerhäuser |
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| E-Jahr: | 2004 |
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| Jahr: | 22 October 2004 |
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| Umfang: | 9 S. |
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| Fussnoten: | Gesehen am 07.12.2020 |
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| Titel Quelle: | Enthalten in: Biochemical and biophysical research communications |
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| Ort Quelle: | Orlando, Fla. : Academic Press, 1959 |
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| Jahr Quelle: | 2004 |
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| Band/Heft Quelle: | 325(2004), 1, Seite 287-295 |
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| ISSN Quelle: | 1090-2104 |
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| Abstract: | Endothelial cells (EC) play a major role in tumor-induced neovascularization and bridge the gap between a microtumor and growth factors such as nutrients and oxygen supply required for expansion. Immortalized human microvascular endothelial cells (HMEC-1) were utilized to assess anti-endothelial effects of 10 novel potential cancer chemopreventive compounds from various sources that we have investigated previously in a human in vitro anti-angiogenic assay. These include the monoacylphloroglucinol isoaspidinol B, 1,2,5,7-tetrahydroxy-anthraquinone, peracetylated carnosic acid (PCA), isoxanthohumol, 2,2′,4′-trimethoxychalcone, 3′-bromo-2,4-dimethoxychalcone as well as four synthetic derivatives of lunularic acid, a bibenzyl found in mosses [Int. J. Cancer Prev. 1 (2004) 47]. EC proliferation was inhibited with half-maximal inhibitory concentrations from 0.3 to 49.6μM, whereas EC migration was affected by most compounds at sub-micromolar concentrations. PCA and the bibenzyl derivative EC 1004 potently prevented differentiation of HMEC-1 into tubule-like structures. Overall, our data indicate that inhibition of endothelial cell function contributes to various extents to the chemopreventive or anti-angiogenic potential of these lead compounds. |
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| DOI: | doi:10.1016/j.bbrc.2004.10.032 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.bbrc.2004.10.032 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S0006291X04023393 |
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| | DOI: https://doi.org/10.1016/j.bbrc.2004.10.032 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Anti-angiogenic |
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| | Anti-endothelial |
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| | Bibenzyls |
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| | Cancer chemoprevention |
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| | Chalcones |
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| | HCT-116 |
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| | Human microvascular endothelial cells |
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| | Migration |
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| | NIH/3T3 |
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| | Polyphenols |
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| | Proliferation |
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| | SK-BR3 |
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| | Tube formation |
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| K10plus-PPN: | 1742221521 |
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| Verknüpfungen: | → Zeitschrift |
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Inhibition of endothelial cell functions by novel potential cancer chemopreventive agents / Bertl, Elisabeth [VerfasserIn]; 22 October 2004 (Online-Ressource)
