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Verfasst von:Burki, Nausherwan K. [VerfasserIn]   i
 Mani, Raj Kumar [VerfasserIn]   i
 Herth, Felix [VerfasserIn]   i
 Schmidt, Werner [VerfasserIn]   i
 Teschler, Helmut [VerfasserIn]   i
 Bonin, Frank [VerfasserIn]   i
 Becker, Heinrich [VerfasserIn]   i
 Randerath, Winfried J. [VerfasserIn]   i
 Stieglitz, Sven [VerfasserIn]   i
 Hagmeyer, Lars [VerfasserIn]   i
 Priegnitz, Christina [VerfasserIn]   i
 Pfeifer, Michael [VerfasserIn]   i
 Blaas, Stefan H. [VerfasserIn]   i
 Putensen, Christian [VerfasserIn]   i
 Theuerkauf, Nils [VerfasserIn]   i
 Quintel, Michael [VerfasserIn]   i
 Moerer, Onnen [VerfasserIn]   i
Titel:A novel extracorporeal CO2 removal system
Titelzusatz:results of a pilot study of hypercapnic respiratory failure in patients with COPD
Verf.angabe:Nausherwan K. Burki, MD, PhD, FCCP; Raj Kumar Mani, MD, FCCP; Felix J.F. Herth, MD, FCCP; Werner Schmidt, MD; Helmut Teschler, MD; Frank Bonin, MD; Heinrich Becker, MD; Winfried J. Randerath, MD, FCCP; Sven Stieglitz, MD; Lars Hagmeyer, MD; Christina Priegnitz, MD; Michael Pfeifer, MD; Stefan H. Blaas, MD; Christian Putensen, MD, PhD; Nils Theuerkauf, MD; Michael Quintel, MD, PhD; and Onnen Moerer, MD
Jahr:2013
Jahr des Originals:2015
Umfang:9 S.
Fussnoten:Available online: 16 December 2015 ; Im Titel ist "2" nach "CO" tiefer gestellt ; Gesehen am 09.12.2020
Titel Quelle:Enthalten in: Chest
Ort Quelle:Amsterdam : Elsevier, 1935
Jahr Quelle:2013
Band/Heft Quelle:143(2013), 3, Seite 678-686
ISSN Quelle:1931-3543
Abstract:Background - Hypercapnic respiratory failure in patients with COPD frequently requires mechanical ventilatory support. Extracorporeal CO2 removal (ECCO2R) techniques have not been systematically evaluated in these patients. - Methods - This is a pilot study of a novel ECCO2R device that utilizes a single venous catheter with high CO2 removal rates at low blood flows. Twenty hypercapnic patients with COPD received ECCO2R. Group 1 (n = 7) consisted of patients receiving noninvasive ventilation with a high likelihood of requiring invasive ventilation, group 2 (n = 2) consisted of patients who could not be weaned from noninvasive ventilation, and group 3 (n = 11) consisted of patients on invasive ventilation who had failed attempts to wean. - Results - The device was well tolerated, with complications and rates similar to those seen with central venous catheterization. Blood flow through the system was 430.5 ± 73.7 mL/min, and ECCO2R was 82.5 ± 15.6 mL/min and did not change significantly with time. Invasive ventilation was avoided in all patients in group 1 and both patients in group 2 were weaned; PaCO2 decreased significantly (P < .003) with application of the device from 78.9 ± 16.8 mm Hg to 65.9 ± 11.5 mm Hg. In group 3, three patients were weaned, while the level of invasive ventilatory support was reduced in three patients. One patient in group 3 died due to a retroperitoneal bleed following catheterization. - Conclusions - This single-catheter, low-flow ECCO2R system provided clinically useful levels of CO2 removal in these patients with COPD. The system appears to be a potentially valuable additional modality for the treatment of hypercapnic respiratory failure. - Trial registry - ClinicalTrials.gov; No.: NCT00987740 and 01021605; URL: www.clinicaltrials.gov
DOI:doi:10.1378/chest.12-0228
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1378/chest.12-0228
 Volltext: http://www.sciencedirect.com/science/article/pii/S0012369213601476
 DOI: https://doi.org/10.1378/chest.12-0228
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1742352952
Verknüpfungen:→ Zeitschrift

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