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| Verfasst von: | Xie, Na [VerfasserIn]  |
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| | Zhang, Lu [VerfasserIn] |
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| | Gao, Wei [VerfasserIn] |
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| | Huang, Canhua [VerfasserIn] |
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| | Huber, Peter E. [VerfasserIn] |
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| | Zhou, Xiao-Bo [VerfasserIn] |
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| | Li, Changlong [VerfasserIn] |
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| | Shen, Guobo [VerfasserIn] |
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| | Zou, Bingwen [VerfasserIn] |
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| Titel: | NAD + metabolism |
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| Titelzusatz: | pathophysiologic mechanisms and therapeutic potential |
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| Verf.angabe: | Na Xie, Lu Zhang, Wei Gao, Canhua Huang, Peter Ernst Huber, Xiaobo Zhou, Changlong Li, Guobo Shen and Bingwen Zou |
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| E-Jahr: | 2020 |
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| Jahr: | 07 October 2020 |
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| Umfang: | 37 S. |
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| Fussnoten: | Im Titel ist "+" hochgestellt ; Gesehen am 10.12.2020 |
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| Titel Quelle: | Enthalten in: Signal transduction and targeted therapy |
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| Ort Quelle: | London : Macmillan Publishers, part of Springer Nature, 2016 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 5(2020), Artikel-ID 227, Seite 1-37 |
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| ISSN Quelle: | 2059-3635 |
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| Abstract: | Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators to maintain physiologic processes, enabling the plastic cells to adapt to environmental changes including nutrient perturbation, genotoxic factors, circadian disorder, infection, inflammation and xenobiotics. These effects are mainly achieved by the driving effect of NAD+ on metabolic pathways as enzyme cofactors transferring hydrogen in oxidation-reduction reactions. Besides, multiple NAD+-dependent enzymes are involved in physiology either by post-synthesis chemical modification of DNA, RNA and proteins, or releasing second messenger cyclic ADP-ribose (cADPR) and NAADP+. Prolonged disequilibrium of NAD+ metabolism disturbs the physiological functions, resulting in diseases including metabolic diseases, cancer, aging and neurodegeneration disorder. In this review, we summarize recent advances in our understanding of the molecular mechanisms of NAD+-regulated physiological responses to stresses, the contribution of NAD+ deficiency to various diseases via manipulating cellular communication networks and the potential new avenues for therapeutic intervention. |
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| DOI: | doi:10.1038/s41392-020-00311-7 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/s41392-020-00311-7 |
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| | Volltext: https://www.nature.com/articles/s41392-020-00311-7 |
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| | DOI: https://doi.org/10.1038/s41392-020-00311-7 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1742408672 |
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| Verknüpfungen: | → Zeitschrift |
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