Status: Bibliographieeintrag
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| Verfasst von: | Bergemann, Niels [VerfasserIn]  |
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| | Abu-Tair, Fatima [VerfasserIn] |
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| | Aderjan, Rolf [VerfasserIn] |
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| | Kopitz, Jürgen [VerfasserIn] |
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| Titel: | High clozapine concentrations in leukocytes in a patient who developed leukocytopenia |
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| Verf.angabe: | Niels Bergemann, Fatima Abu-Tair, Rolf Aderjan, Jürgen Kopitz |
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| E-Jahr: | 2007 |
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| Jahr: | 23 March 2007 |
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| Umfang: | 4 S. |
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| Fussnoten: | Gesehen am 10.12.2020 |
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| Titel Quelle: | Enthalten in: Progress in neuro-psychopharmacology & biological psychiatry |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1982 |
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| Jahr Quelle: | 2007 |
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| Band/Heft Quelle: | 31(2007), 5, Seite 1068-1071 |
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| ISSN Quelle: | 1878-4216 |
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| Abstract: | Up to now direct toxic effects or immunological processes have been said to explain clozapine-induced agranulocytosis. However, more recent studies may suggest that not yet metabolized clozapine is taken up by leukocytes and transformed by oxidative processes to apoptosis-inducing metabolites. To verify this hypothesis the concentrations of clozapine were measured in the plasma and the leukocytes of a patient receiving clozapine who developed clozapine-induced leukocytopenia and in 10 patients receiving clozapine who did not show any serious adverse side effects. The patient who developed leukocytopenia showed clozapine concentrations in the leukocytes that were about 8 times higher than the mean clozapine concentrations in the leukocytes in the group of 10 patients receiving clozapine with no changes in the leukocyte count in the history. However, no major difference was found in the clozapine plasma concentrations. The results may suggest that patients at risk of developing clozapine-induced leukocytopenia show increased clozapine concentrations in the leukocytes although the clozapine plasma concentration is in the therapeutic range. It is assumed that changes or abnormalities of clozapine uptake at the cell membrane might play a role in the development of clozapine-induced leukocytopenia and/or agranulocytosis. |
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| DOI: | doi:10.1016/j.pnpbp.2007.03.009 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.pnpbp.2007.03.009 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S0278584607001030 |
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| | DOI: https://doi.org/10.1016/j.pnpbp.2007.03.009 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Clozapine |
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| | Clozapine concentrations in leukocytes |
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| | Clozapine plasma concentration |
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| | Clozapine transporter |
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| | Clozapine-induced agranulocytosis |
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| K10plus-PPN: | 1742414362 |
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| Verknüpfungen: | → Zeitschrift |
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High clozapine concentrations in leukocytes in a patient who developed leukocytopenia / Bergemann, Niels [VerfasserIn]; 23 March 2007 (Online-Ressource)
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