| Online-Ressource |
Verfasst von: | Simon, Joe J. [VerfasserIn]  |
| Stopyra, Marion A. [VerfasserIn]  |
| Mönning, Esther [VerfasserIn]  |
| Sailer, Sebastian [VerfasserIn]  |
| Lavandier, Nora [VerfasserIn]  |
| Kihm, Lars Philipp [VerfasserIn]  |
| Bendszus, Martin [VerfasserIn]  |
| Preißl, Hubert [VerfasserIn]  |
| Herzog, Wolfgang [VerfasserIn]  |
| Friederich, Hans-Christoph [VerfasserIn]  |
Titel: | Neuroimaging of hypothalamic mechanisms related to glucose metabolism in anorexia nervosa and obesity |
Verf.angabe: | Joe J. Simon, Marion A. Stopyra, Esther Mönning, Sebastian Sailer, Nora Lavandier, Lars P. Kihm, Martin Bendszus, Hubert Preissl, Wolfgang Herzog, and Hans-Christoph Friederich |
E-Jahr: | 2020 |
Jahr: | April 21, 2020 |
Umfang: | 10 S. |
Fussnoten: | Gesehen am 10.12.2020 |
Titel Quelle: | Enthalten in: The journal of clinical investigation |
Ort Quelle: | Ann Arbor, Mich. : ASCJ, 1924 |
Jahr Quelle: | 2020 |
Band/Heft Quelle: | 130(2020), 8, Seite 4094-4103 |
ISSN Quelle: | 1558-8238 |
Abstract: | Background: Given the heightened tolerance to self-starvation in anorexia nervosa (AN), a hypothalamic dysregulation of energy and glucose homeostasis has been hypothesized. Therefore, we investigated whether hypothalamic reactivity to glucose metabolism is impaired in AN. Methods: Twenty-four participants with AN, 28 normal-weight participants, and 24 healthy participants with obesity underwent 2 MRI sessions in a single-blind, randomized, case-controlled crossover study. We used an intragastric infusion of glucose and water to bypass the cephalic phase of food intake. The responsivity of the hypothalamus and the crosstalk of the hypothalamus with reward-related brain regions were investigated using high-resolution MRI. Results: Normal-weight control participants displayed the expected glucose-induced deactivation of hypothalamic activation, whereas patients with AN and participants with obesity showed blunted hypothalamic reactivity. Furthermore, patients with AN displayed blunted reactivity in the nucleus accumbens and amygdala. Compared with the normal-weight participants and control participants with obesity, the patients with AN failed to show functional connectivity between the hypothalamus and the reward-related brain regions during water infusion relative to glucose infusion. Finally, the patients with AN displayed typical baseline levels of peripheral appetite hormones during a negative energy balance. Conclusion: These results indicate that blunted hypothalamic glucose reactivity might be related to the pathophysiology of AN. This study provides insights for future research, as it is an extended perspective of the traditional primary nonhomeostatic understanding of the disease. |
DOI: | doi:10.1172/JCI136782 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1172/JCI136782 |
| Volltext: https://www.jci.org/articles/view/136782 |
| DOI: https://doi.org/10.1172/JCI136782 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1742422268 |
Verknüpfungen: | → Zeitschrift |
Neuroimaging of hypothalamic mechanisms related to glucose metabolism in anorexia nervosa and obesity / Simon, Joe J. [VerfasserIn]; April 21, 2020 (Online-Ressource)