Quantitative susceptibility mapping differentiates between blood depositions and calcifications in patients with glioblastoma

• Verfasst von: Deistung, Andreas [VerfasserIn]
• Verfasst von: Schweser, Ferdinand [VerfasserIn]
• Verfasst von: Wiestler, Benedikt [VerfasserIn]
• Verfasst von: Abello, Mario [VerfasserIn]
• Verfasst von: Röthke, Matthias C. [VerfasserIn]
• Verfasst von: Sahm, Felix [VerfasserIn]
• Verfasst von: Wick, Wolfgang [VerfasserIn]
• Verfasst von: Nagel, Armin Michael [VerfasserIn]
• Verfasst von: Heiland, Sabine [VerfasserIn]
• Verfasst von: Schlemmer, Heinz-Peter [VerfasserIn]
• Verfasst von: Bendszus, Martin [VerfasserIn]
• Verfasst von: Reichenbach, Jürgen Rainer [VerfasserIn]
• Verfasst von: Radbruch, Alexander [VerfasserIn]
• Titel: Quantitative susceptibility mapping differentiates between blood depositions and calcifications in patients with glioblastoma
• Verf.angabe: Andreas Deistung, Ferdinand Schweser, Benedikt Wiestler, Mario Abello, Matthias Roethke, Felix Sahm, Wolfgang Wick, Armin Michael Nagel, Sabine Heiland, Heinz-Peter Schlemmer, Martin Bendszus, Jürgen Rainer Reichenbach, Alexander Radbruch
• E-Jahr: 2013
• Jahr: March 21, 2013
• Fussnoten: Gesehen am 10.12.2020
• Titel Quelle: Enthalten in: PLOS ONE
• Ort Quelle: San Francisco, California, US : PLOS, 2006
• Jahr Quelle: 2013
• Band/Heft Quelle: 8(2013,3) Artikel-Nummer e57924, 8 Seiten
• ISSN Quelle: 1932-6203
• DOI: doi:10.1371/journal.pone.0057924
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Blood
• Sach-SW: Brain mapping
• Sach-SW: Calcification
• Sach-SW: Cancer detection and diagnosis
• Sach-SW: Cancers and neoplasms
• Sach-SW: Glioblastoma multiforme
• Sach-SW: Magnetic resonance imaging
• Sach-SW: Sedentary behavior
• K10plus-PPN: 1742494463

Abstract

Objectives The application of susceptibility weighted imaging (SWI) in brain tumor imaging is mainly used to assess tumor-related “susceptibility based signals” (SBS). The origin of SBS in glioblastoma is still unknown, potentially representing calcifications or blood depositions. Reliable differentiation between both entities may be important to evaluate treatment response and to identify glioblastoma with oligodendroglial components that are supposed to present calcifications. Since calcifications and blood deposits are difficult to differentiate using conventional MRI, we investigated whether a new post-processing approach, quantitative susceptibility mapping (QSM), is able to distinguish between both entities reliably. Materials and Methods SWI, FLAIR, and T1-w images were acquired from 46 patients with glioblastoma (14 newly diagnosed, 24 treated with radiochemotherapy, 8 treated with radiochemotherapy and additional anti-angiogenic medication). Susceptibility maps were calculated from SWI data. All glioblastoma were evaluated for the appearance of hypointense or hyperintense correlates of SBS on the susceptibility maps. Results 43 of 46 glioblastoma presented only hyperintense intratumoral SBS on susceptibility maps, indicating blood deposits. Additional hypointense correlates of tumor-related SBS on susceptibility maps, indicating calcification, were identified in 2 patients being treated with radiochemotherapy and in one patient being treated with additional anti-angiogenic medication. Histopathologic reports revealed an oligodendroglial component in one patient that presented calcifications on susceptibility maps. Conclusions QSM provides a quantitative, local MRI contrast, which reliably differentiates between blood deposits and calcifications. Thus, quantitative susceptibility mapping appears promising to identify rare variants of glioblastoma with oligodendroglial components non-invasively and may allow monitoring the role of calcification in the context of different therapy regimes.