| |  Online-Ressource |
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| Verfasst von: | Coulibaly, Boubacar [VerfasserIn]  |
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| | Pritsch, Michael [VerfasserIn] |
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| | Bountogo, Mamadou [VerfasserIn] |
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| | Meissner, Peter [VerfasserIn] |
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| | Nebié, Eric [VerfasserIn] |
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| | Klose, Christina [VerfasserIn] |
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| | Kieser, Meinhard [VerfasserIn] |
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| | Berens-Riha, Nicole [VerfasserIn] |
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| | Wieser, Andreas [VerfasserIn] |
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| | Sirima, Sodiomon [VerfasserIn] |
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| | Breitkreutz, Jörg [VerfasserIn] |
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| | Schirmer, Rolf Heiner [VerfasserIn] |
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| | Sié, Ali [VerfasserIn] |
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| | Mockenhaupt, Frank Peter [VerfasserIn] |
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| | Drakeley, Chris [VerfasserIn] |
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| | Bousema, Teun [VerfasserIn] |
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| | Müller, Olaf [VerfasserIn] |
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| Titel: | Efficacy and safety of triple combination therapy with artesunate-amodiaquine-methylene blue for falciparum malaria in children |
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| Titelzusatz: | a randomized controlled trial in Burkina Faso |
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| Verf.angabe: | Boubacar Coulibaly, Michael Pritsch, Mamadou Bountogo, Peter E. Meissner, Eric Nebié, Christina Klose, Meinhard Kieser, Nicole Berens-Riha, Andreas Wieser, Sodiomon B. Sirima, Jörg Breitkreutz, R. Heiner Schirmer, Ali Sié, Frank P. Mockenhaupt, Chris Drakeley, Teun Bousema, and Olaf Müller |
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| E-Jahr: | 2015 |
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| Jahr: | 1 March 2015 |
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| Umfang: | 9 S. |
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| Fussnoten: | Gesehen am 10.12.2020 ; Published:28 September 2014 |
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| Titel Quelle: | Enthalten in: The journal of infectious diseases |
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| Ort Quelle: | Oxford [u.a.] : Oxford Univ. Press, 1904 |
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| Jahr Quelle: | 2015 |
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| Band/Heft Quelle: | 211(2015), 5, Seite 689-697 |
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| ISSN Quelle: | 1537-6613 |
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| Abstract: | Background. Methylene blue (MB) has been shown to be safe and effective against falciparum malaria in Africa and to have pronounced gametocytocidal properties.Methods. Three days of treatment with artesunate (AS)-amodiaquine (AQ) combined with MB was compared with AS-AQ treatment in a randomized controlled phase IIb study; the study included 221 children aged 6-59 months with uncomplicated falciparum malaria in Burkina Faso. The primary end point was gametocyte prevalence during follow-up, as determined by microscopy and real-time quantitative nucleic acid sequence-based amplification (QT-NASBA).Results. The gametocyte prevalence of Plasmodium falciparum at baseline was 3.6% (microscopy) and 97% (QT-NASBA). It was significantly lower in the AS-AQ-MB than in the AS-AQ group on day 7 of follow-up (microscopy, 1.2% vs 8.9% [P < .05]; QT-NASBA, 36.7% vs 63.3% [P < .001]). Hemoglobin values were significantly lower in the AS-AQ-MB group than in the AS-AQ group at days 2 and 7 of follow-up. Vomiting of the study medication occurred significantly more frequently in the AS-AQ-MB group.Conclusions. The combination of MB with an artemisinin-based combination therapy has been confirmed to be effective against the gametocytes of P. falciparum. MB-based combinations need to be compared with primaquine-based combinations, preferably using MB in an improved pediatric formulation.Clinical Trials Registration. NCT01407887. |
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| DOI: | doi:10.1093/infdis/jiu540 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1093/infdis/jiu540 |
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| | DOI: https://doi.org/10.1093/infdis/jiu540 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1742497314 |
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| Verknüpfungen: | → Zeitschrift |
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Efficacy and safety of triple combination therapy with artesunate-amodiaquine-methylene blue for falciparum malaria in children / Coulibaly, Boubacar [VerfasserIn]; 1 March 2015 (Online-Ressource)
