| |  Online-Ressource |
|---|
| Verfasst von: | Nau, Barbara Silvia [VerfasserIn]  |
|---|
| | Schmitt, Claus P. [VerfasserIn] |
|---|
| | Almeida, Margarida [VerfasserIn] |
|---|
| | Arbeiter, Klaus [VerfasserIn] |
|---|
| | Ardissino, Gianluigi [VerfasserIn] |
|---|
| | Bonzel, Klaus E. [VerfasserIn] |
|---|
| | Edefonti, Alberto [VerfasserIn] |
|---|
| | Fischbach, Michel [VerfasserIn] |
|---|
| | Haluany, Karin [VerfasserIn] |
|---|
| | Misselwitz, Joachim [VerfasserIn] |
|---|
| | Kemper, Markus J. [VerfasserIn] |
|---|
| | Rönnholm, Kai [VerfasserIn] |
|---|
| | Wygoda, Simone [VerfasserIn] |
|---|
| | Schaefer, Franz [VerfasserIn] |
|---|
| Titel: | BIOKID |
|---|
| Titelzusatz: | randomized controlled trial comparing bicarbonate and lactate buffer in biocompatible peritoneal dialysis solutions in children [ISRCTN81137991] |
|---|
| Verf.angabe: | Barbara Nau, Claus P. Schmitt, Margarida Almeida, Klaus Arbeiter, Gianluigi Ardissino, Klaus E. Bonzel, Alberto Edefonti, Michel Fischbach, Karin Haluany, Joachim Misselwitz, Markus J. Kemper, Kai Rönnholm, Simone Wygoda, Franz Schaefer, European Pediatric Peritoneal Dialysis Study Group (EPPS) |
|---|
| E-Jahr: | 2004 |
|---|
| Jahr: | 14 October 2004 |
|---|
| Umfang: | 6 S. |
|---|
| Teil: | volume:5 |
|---|
| | year:2004 |
|---|
| | elocationid:14 |
|---|
| | pages:1-6 |
|---|
| | extent:6 |
|---|
| Fussnoten: | Gesehen am 10.12.2020 |
|---|
| Titel Quelle: | Enthalten in: BMC nephrology |
|---|
| Ort Quelle: | London : BioMed Central, 2000 |
|---|
| Jahr Quelle: | 2004 |
|---|
| Band/Heft Quelle: | 5(2004), Artikel-ID 14, Seite 1-6 |
|---|
| ISSN Quelle: | 1471-2369 |
|---|
| Abstract: | Peritoneal dialysis (PD) is the preferred dialysis modality in children. Its major drawback is the limited technique survival due to infections and progressive ultrafiltration failure. Conventional PD solutions exert marked acute and chronic toxicity to local tissues. Prolonged exposure is associated with severe histopathological alterations including vasculopathy, neoangiogenesis, submesothelial fibrosis and a gradual loss of the mesothelial cell layer. Recently, more biocompatible PD solutions containing reduced amounts of toxic glucose degradation products (GDPs) and buffered at neutral pH have been introduced into clinical practice. These solutions contain lactate, bicarbonate or a combination of both as buffer substance. Increasing evidence from clinical trials in adults and children suggests that the new PD fluids may allow for better long-term preservation of peritoneal morphology and function. However, the relative importance of the buffer in neutral-pH, low-GDP fluids is still unclear. In vitro, lactate is cytotoxic and vasoactive at the concentrations used in PD fluids. The BIOKID trial is designed to clarify the clinical significance of the buffer choice in biocompatible PD fluids. |
|---|
| DOI: | doi:10.1186/1471-2369-5-14 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1186/1471-2369-5-14 |
|---|
| | Volltext: https://bmcnephrol.biomedcentral.com/articles/10.1186/1471-2369-5-14 |
|---|
| | DOI: https://doi.org/10.1186/1471-2369-5-14 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Mesothelial Cell |
|---|
| | Peritoneal Dialysis |
|---|
| | Peritoneal Dialysis Fluid |
|---|
| | Peritoneal Dialysis Solution |
|---|
| | Sevelamer |
|---|
| K10plus-PPN: | 174250101X |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
