| |  Online-Ressource |
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| Verfasst von: | Dally, Heike [VerfasserIn]  |
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| | Bartsch, Helmut [VerfasserIn] |
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| | Edler, Lutz [VerfasserIn] |
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| | Schmezer, Peter [VerfasserIn] |
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| | Spiegelhalder, Bertold [VerfasserIn] |
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| | Dienemann, Hendrik [VerfasserIn] |
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| | Drings, Peter [VerfasserIn] |
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| | Kayser, Klaus [VerfasserIn] |
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| | Schulz, Volker [VerfasserIn] |
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| | Risch, Angela [VerfasserIn] |
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| Titel: | Genotype relationships in the CYP3A locus in Caucasians |
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| Verf.angabe: | Heike Dally, Helmut Bartsch, Birgit Jäger, Lutz Edler, Peter Schmezer, Bertold Spiegelhalder, Hendrik Dienemann, Peter Drings, Klaus Kayser, Volker Schulz, Angela Risch |
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| E-Jahr: | 2004 |
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| Jahr: | 7 February 2004 |
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| Umfang: | 5 S. |
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| Fussnoten: | Gesehen am 11.12.2020 |
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| Titel Quelle: | Enthalten in: Cancer letters |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1975 |
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| Jahr Quelle: | 2004 |
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| Band/Heft Quelle: | 207(2004), Seite 95-99 |
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| ISSN Quelle: | 1872-7980 |
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| Abstract: | Genetic polymorphisms of the human CYP3A family affect clinical drug efficacy and may modify cancer risk. CYP3A genes show high sequence similarity that had previously lead to misallocation of CYP3A polymorphisms. Recent studies indicated a high degree of or even complete linkage for certain CYP3A alleles. Reliable LightCycler-based genotyping methods were developed and their degree of linkage in a large Caucasian population (n=1210) investigated. Strong linkage disequilibrium was confirmed between CYP3A4, CYP3A5, and CYP3AP1 (each at P<10−5). Contrary to some previous results claiming complete linkage between the phenotypically relevant CYP3A5*1 and a variant in a pseudogene promoter region CYP3AP1*1, we found among 428 controls (15 of 66) and 782 lung cancer cases (25 of 115) approximately 22% of CYP3AP1*1/*3 carriers to be homozygous for CYP3A5*3. We conclude that contrary to previous assumptions, the CYP3AP1 genotype is not a reliable predictor for CYP3A5 activity. |
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| DOI: | doi:10.1016/j.canlet.2003.12.011 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.canlet.2003.12.011 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S0304383503008528 |
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| | DOI: https://doi.org/10.1016/j.canlet.2003.12.011 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Linkage disequilibrium |
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| | Polymorphism |
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| | Pseudogene |
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| K10plus-PPN: | 1742613357 |
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| Verknüpfungen: | → Zeitschrift |
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Genotype relationships in the CYP3A locus in Caucasians / Dally, Heike [VerfasserIn]; 7 February 2004 (Online-Ressource)
