| |  Online-Ressource |
|---|
| Verfasst von: | Bergemann, Niels [VerfasserIn]  |
|---|
| | Mundt, Christoph [VerfasserIn] |
|---|
| | Parzer, Peter [VerfasserIn] |
|---|
| | Pakrasi, Manoshi [VerfasserIn] |
|---|
| | Eckstein-Mannsperger, Ursula [VerfasserIn] |
|---|
| | Haisch-Gomes, Susanne [VerfasserIn] |
|---|
| | Salbach, Birgitt Ines Angela [VerfasserIn] |
|---|
| | Klinga, Klaus [VerfasserIn] |
|---|
| | Runnebaum, Benno [VerfasserIn] |
|---|
| | Resch, Franz [VerfasserIn] |
|---|
| Titel: | Estrogen as an adjuvant therapy to antipsychotics does not prevent relapse in women suffering from schizophrenia |
|---|
| Titelzusatz: | results of a placebo-controlled double-blind study |
|---|
| Verf.angabe: | Niels Bergemann, Christoph Mundt, Peter Parzer, Manoshi Pakrasi, Ursula Eckstein-Mannsperger, Susanne Haisch, Birgitt Salbach, Klaus Klinga, Benno Runnebaum, Franz Resch |
|---|
| E-Jahr: | 2005 |
|---|
| Jahr: | 13 January 2005 |
|---|
| Umfang: | 10 S. |
|---|
| Fussnoten: | Gesehen am 15.12.2020 |
|---|
| Titel Quelle: | Enthalten in: Schizophrenia research |
|---|
| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1988 |
|---|
| Jahr Quelle: | 2005 |
|---|
| Band/Heft Quelle: | 74(2005), 2, Seite 125-134 |
|---|
| ISSN Quelle: | 1573-2509 |
|---|
| Abstract: | The expected therapeutic effect of estrogen as an adjunct treatment to antipsychotics in women suffering from schizophrenia for relapse prevention was to be tested under real-life conditions. A multicenter, randomized, placebo-controlled, double-blind, cross-over study based on an A-B-A-B (and/or B-A-B-A) design was applied. Forty-six hypoestrogenic women with schizophrenia hospitalized for the first time or repeatedly were included in the study. Their average age was 37.9 and they had been suffering from schizophrenia for 8.4 years. During the drug treatment phases, they received a three-phase estrogen-gestagen combination drug (17β-estradiol+norethisterone acetate) in addition to an antipsychotic drug. Significant effects of the adjuvant hormone replacement therapy on the estradiol levels could be observed, and high and low levels of estradiol prevailed in the active drug and placebo phases, respectively. We did not find any difference either in defined relapse events or in the psychopathology between estradiol replacement and placebo phases. Neither did the required antipsychotic doses or the tolerance data differ between the two phases. Thus, the results of our study do not confirm the hypothesis that a combined estradiol/antipsychotic therapy is superior to an antipsychotic monotherapy for relapse prevention. |
|---|
| DOI: | doi:10.1016/j.schres.2004.12.009 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.schres.2004.12.009 |
|---|
| | Volltext: http://www.sciencedirect.com/science/article/pii/S0920996404004669 |
|---|
| | DOI: https://doi.org/10.1016/j.schres.2004.12.009 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Estradiol |
|---|
| | Estrogen protection hypothesis |
|---|
| | Estrogens |
|---|
| | Hormone replacement therapy |
|---|
| | Hypoestrogenism |
|---|
| | Schizophrenia |
|---|
| K10plus-PPN: | 1742822142 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Estrogen as an adjuvant therapy to antipsychotics does not prevent relapse in women suffering from schizophrenia / Bergemann, Niels [VerfasserIn]; 13 January 2005 (Online-Ressource)
