Inter-observer reproducibility of semi-automatic tumor diameter measurement and volumetric analysis in patients with lung cancer

• Verfasst von: Dinkel, Julien [VerfasserIn]
• Verfasst von: Khalilzadeh, O. [VerfasserIn]
• Verfasst von: Hintze, C. [VerfasserIn]
• Verfasst von: Fabel, M. [VerfasserIn]
• Verfasst von: Puderbach, Michael [VerfasserIn]
• Verfasst von: Eichinger, Monika [VerfasserIn]
• Verfasst von: Schlemmer, Heinz-Peter [VerfasserIn]
• Verfasst von: Thorn, M. [VerfasserIn]
• Verfasst von: Heußel, Claus Peter [VerfasserIn]
• Verfasst von: Thomas, Michael [VerfasserIn]
• Verfasst von: Kauczor, Hans-Ulrich [VerfasserIn]
• Verfasst von: Biederer, Jürgen [VerfasserIn]
• Titel: Inter-observer reproducibility of semi-automatic tumor diameter measurement and volumetric analysis in patients with lung cancer
• Verf.angabe: J. Dinkel, O. Khalilzadeh, C. Hintze, M. Fabel, M. Puderbach, M. Eichinger, H.-P. Schlemmer, M. Thorn, C.P. Heussel, M. Thomas, H.-U. Kauczor, J. Biederer
• E-Jahr: 2013
• Jahr: 8 August 2013
• Umfang: 7 S.
• Fussnoten: Gesehen am 16.12.2020
• Titel Quelle: Enthalten in: Lung cancer
• Ort Quelle: Amsterdam [u.a.] : Elsevier, 1985
• Jahr Quelle: 2013
• Band/Heft Quelle: 82(2013), 1, Seite 76-82
• ISSN Quelle: 1872-8332
• DOI: doi:10.1016/j.lungcan.2013.07.006
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Inter-rater reliability
• Sach-SW: Lung cancer
• Sach-SW: RECIST guideline
• Sach-SW: Tumor size
• Sach-SW: Volumetric analysis
• Sach-SW: WHO guideline
• K10plus-PPN: 1743053649

Abstract

Objectives - Therapy monitoring in oncologic patient requires precise measurement methods. In order to improve the precision of measurements, we used a semi-automated generic segmentation algorithm to measure the size of large lung cancer tumors. The reproducibility of computer-assisted measurements were assessed and compared with manual measurements. - Methods - CT scans of 24 consecutive lung cancer patients who were referred to our hospital over a period of 6 months were analyzed. The tumor sizes were measured manually by 3 independent radiologists, according to World Health Organization (WHO) and the Revised Response Evaluation Criteria in Solid Tumors (RECIST) guidelines. At least 10 months later, measurements were repeated semi-automatically on the same scans by the same radiologists. The inter-observer reproducibility of all measurements was assessed and compared between manual and semi-automated measurements. - Results - Manual measurements of the tumor longest diameter were significantly (p<0.05) smaller compared with the semi-automated measurements. The intra-rater correlations coefficients were significantly higher for measurements of longest diameter (intra-class correlation coefficients: 0.998 vs. 0.986; p<0.001) and area (0.995 vs. 0.988; p=0.032) using semi-automated compared with manual method. The variation coefficient for manual measurement of the tumor area (WHO guideline, 15.7% vs. 7.3%) and the longest diameter (RECIST guideline, 7.7% vs. 2.7%) was 2-3 times that of semi-automated measurement. - Conclusions - By using computer-assisted size assessment in primary lung tumor, interobserver-variability can be reduced to about half to one-third compared to standard manual measurements. This indicates a high potential value for therapy monitoring in lung cancer patients.