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| Verfasst von: | Asiimwe, Stephen B. [VerfasserIn]  |
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| | Farrell, Meagan [VerfasserIn] |
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| | Kobayashi, Lindsay C. [VerfasserIn] |
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| | Manne-Goehler, Jen [VerfasserIn] |
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| | Kahn, Kathleen [VerfasserIn] |
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| | Tollman, Stephen M. [VerfasserIn] |
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| | Kabudula, Chodziwadziwa Whiteson [VerfasserIn] |
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| | Gómez-Olivé, F. Xavier [VerfasserIn] |
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| | Wagner, Ryan G. [VerfasserIn] |
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| | Montana, Livia [VerfasserIn] |
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| | Berkman, Lisa F. [VerfasserIn] |
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| | Glymour, M. Maria [VerfasserIn] |
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| | Bärnighausen, Till [VerfasserIn] |
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| Titel: | Cognitive differences associated with HIV serostatus and antiretroviral therapy use in a population-based sample of older adults in South Africa |
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| Verf.angabe: | Stephen B. Asiimwe, Meagan Farrell, Lindsay C. Kobayashi, Jen Manne-Goehler, Kathleen Kahn, Stephen M. Tollman, Chodziwadziwa Whiteson Kabudula, F. Xavier Gómez-Olivé, Ryan G. Wagner, Livia Montana, Lisa F. Berkman, M. Maria Glymour & Till Bärnighausen |
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| E-Jahr: | 2020 |
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| Jahr: | 06 October 2020 |
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| Umfang: | 14 S. |
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| Fussnoten: | Gesehen am 17.12.2020 |
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| Titel Quelle: | Enthalten in: Scientific reports |
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| Ort Quelle: | [London] : Macmillan Publishers Limited, part of Springer Nature, 2011 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 10(2020) Artikel-Nummer 16625, 14 Seiten |
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| ISSN Quelle: | 2045-2322 |
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| Abstract: | Previous clinical studies have reported adverse cognitive outcomes for people living with HIV (PLWH), but there are no population-based studies comparing cognitive function between older PLWH and comparators without HIV in sub-Saharan Africa. We analyzed baseline data of 40 + years-old participants in “Health and Aging in Africa: A Longitudinal Study of an INDEPTH Community in South Africa” (HAALSI) cohort. We measured cognition using a battery of conventional instruments assessing orientation, immediate- and delayed-recall, and numeracy (N = 4560), and the Oxford Cognitive Screen [OCS]-Plus, a novel instrument for low-literacy populations, assessing memory, language, visual-spatial ability, and executive functioning (N = 1997). Linear regression models comparing cognitive scores between participants with and without HIV were adjusted for sex, education, age, country of birth, father’s occupation, ever-consumed alcohol, and asset index. PLWH scored on average 0.06 (95% CI 0.01-0.12) standard deviation (SD) units higher on the conventional cognitive function measure and 0.02 (95% CI − 0.07 to 0.04) SD units lower on the OCS-Plus measure than HIV-negative participants. We found higher cognitive function scores for PLWH compared to people without HIV when using a conventional measure of cognitive function but not when using a novel instrument for low-literacy settings. |
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| DOI: | doi:10.1038/s41598-020-73689-7 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/s41598-020-73689-7 |
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| | Volltext: https://www.nature.com/articles/s41598-020-73689-7 |
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| | DOI: https://doi.org/10.1038/s41598-020-73689-7 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1743102763 |
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| Verknüpfungen: | → Zeitschrift |
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Cognitive differences associated with HIV serostatus and antiretroviral therapy use in a population-based sample of older adults in South Africa / Asiimwe, Stephen B. [VerfasserIn]; 06 October 2020 (Online-Ressource)
