| Online-Ressource |
Verfasst von: | El-Najjar, Inas [VerfasserIn]  |
| Boumendil, A. [VerfasserIn]  |
| Luan, J. J. [VerfasserIn]  |
| Bouabdallah, R. [VerfasserIn]  |
| Thomson, K. [VerfasserIn]  |
| Mohty, M. [VerfasserIn]  |
| Colombat, P. [VerfasserIn]  |
| Biron, P. [VerfasserIn]  |
| Tilly, H. [VerfasserIn]  |
| Pfreundschuh, M. [VerfasserIn]  |
| Cordonnier, C. [VerfasserIn]  |
| Sureda, A. [VerfasserIn]  |
| Cahn, J. Y. [VerfasserIn]  |
| Vernant, J. P. [VerfasserIn]  |
| Gribben, J. [VerfasserIn]  |
| Cook, G. [VerfasserIn]  |
| Haynes, A. P. [VerfasserIn]  |
| Ferrant, A. [VerfasserIn]  |
| Finel, H. [VerfasserIn]  |
| Montoto, S. [VerfasserIn]  |
| Dreger, Peter [VerfasserIn]  |
Titel: | The impact of total body irradiation on the outcome of patients with follicular lymphoma treated with autologous stem-cell transplantation in the modern era |
Titelzusatz: | a retrospective study of the EBMT Lymphoma Working Party |
Institutionen: | European Group for Blood and Marrow Transplantation [AuftraggeberIn]  |
Verf.angabe: | I. El-Najjar, A. Boumendil, J.J. Luan, R. Bouabdallah, K. Thomson, M. Mohty, P. Colombat, P. Biron, H. Tilly, M. Pfreundschuh, C. Cordonnier, A. Sureda, J.Y. Cahn, J.P. Vernant, J. Gribben, G. Cook, A.P. Haynes, A. Ferrant, H. Finel, S. Montoto, P. Dreger on behalf of the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation (EBMT) |
E-Jahr: | 2014 |
Jahr: | 5 September 2014 |
Umfang: | 6 S. |
Fussnoten: | Gesehen am 17.12.2020 |
Titel Quelle: | Enthalten in: Annals of oncology |
Ort Quelle: | Amsterdam [u.a. : Elsevier, 1990 |
Jahr Quelle: | 2014 |
Band/Heft Quelle: | 25(2014), 11, Seite 2224-2229 |
ISSN Quelle: | 1569-8041 |
Abstract: | BACKGROUND: The aim of this study was to investigate the impact of the high-dose regimen on the outcome of patients with follicular lymphoma (FL) having had autologous stem-cell transplantation (ASCT) in a recent time period. - PATIENTS: Between 1995 and 2007, 2233 patients with FL had their first ASCT with either a total body irradiation (TBI)-containing regimen or carmustin, etoposide, cytarabine and melphalan (BEAM), of which 47% were autografted in first remission. - RESULTS: After a median observation time of 73 months (interquartile range 30-107), 5- and 10-year non-relapse mortality (NRM) was similar (6% and 10% in both groups). No significant NRM differences became evident after multivariate adjustment for confounders. Secondary malignancies were observed in 9.7% and 7.9% of the patients after TBI and BEAM (P = 0.19), which were treatment-related myelodysplastic syndromes/acute myelogenous leukaemia (t-MDS/AML) in 3.4% and 2.8% (P = 0.57). The median time to t-MDS/AML was around 50 months in both groups. Because of a lower relapse incidence, TBI was associated with better event-free survival reaching statistical significance in the patients transplanted in first remission but not in those transplanted beyond first remission. - CONCLUSIONS: In patients with FL who received TBI-based ASCT after 1995 increased NRM and t-MDS/AML risks did not emerge compared with BEAM while disease control was at least equivalent. |
DOI: | doi:10.1093/annonc/mdu440 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1093/annonc/mdu440 |
| DOI: https://doi.org/10.1093/annonc/mdu440 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Adolescent |
| Adult |
| Aged |
| Antibodies, Monoclonal, Murine-Derived |
| Antineoplastic Combined Chemotherapy Protocols |
| Carmustine |
| Combined Modality Therapy |
| Cytarabine |
| Disease-Free Survival |
| Female |
| follicular lymphoma |
| Humans |
| Lymphoma, Follicular |
| Male |
| Melphalan |
| Middle Aged |
| Neoplasm Recurrence, Local |
| Podophyllotoxin |
| Remission Induction |
| rituximab |
| Rituximab |
| secondary malignancies |
| Stem Cell Transplantation |
| t-MDS/AML |
| total body irradiation |
| transplantation |
| Transplantation, Autologous |
| Whole-Body Irradiation |
| Young Adult |
K10plus-PPN: | 1743118694 |
Verknüpfungen: | → Zeitschrift |
¬The¬ impact of total body irradiation on the outcome of patients with follicular lymphoma treated with autologous stem-cell transplantation in the modern era / El-Najjar, Inas [VerfasserIn]; 5 September 2014 (Online-Ressource)