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Status: Bibliographieeintrag

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Verfasst von:El-Najjar, Inas [VerfasserIn]   i
 Boumendil, A. [VerfasserIn]   i
 Luan, J. J. [VerfasserIn]   i
 Bouabdallah, R. [VerfasserIn]   i
 Thomson, K. [VerfasserIn]   i
 Mohty, M. [VerfasserIn]   i
 Colombat, P. [VerfasserIn]   i
 Biron, P. [VerfasserIn]   i
 Tilly, H. [VerfasserIn]   i
 Pfreundschuh, M. [VerfasserIn]   i
 Cordonnier, C. [VerfasserIn]   i
 Sureda, A. [VerfasserIn]   i
 Cahn, J. Y. [VerfasserIn]   i
 Vernant, J. P. [VerfasserIn]   i
 Gribben, J. [VerfasserIn]   i
 Cook, G. [VerfasserIn]   i
 Haynes, A. P. [VerfasserIn]   i
 Ferrant, A. [VerfasserIn]   i
 Finel, H. [VerfasserIn]   i
 Montoto, S. [VerfasserIn]   i
 Dreger, Peter [VerfasserIn]   i
Titel:The impact of total body irradiation on the outcome of patients with follicular lymphoma treated with autologous stem-cell transplantation in the modern era
Titelzusatz:a retrospective study of the EBMT Lymphoma Working Party
Institutionen:European Group for Blood and Marrow Transplantation [AuftraggeberIn]   i
Verf.angabe:I. El-Najjar, A. Boumendil, J.J. Luan, R. Bouabdallah, K. Thomson, M. Mohty, P. Colombat, P. Biron, H. Tilly, M. Pfreundschuh, C. Cordonnier, A. Sureda, J.Y. Cahn, J.P. Vernant, J. Gribben, G. Cook, A.P. Haynes, A. Ferrant, H. Finel, S. Montoto, P. Dreger on behalf of the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation (EBMT)
E-Jahr:2014
Jahr:5 September 2014
Umfang:6 S.
Fussnoten:Gesehen am 17.12.2020
Titel Quelle:Enthalten in: Annals of oncology
Ort Quelle:Amsterdam [u.a. : Elsevier, 1990
Jahr Quelle:2014
Band/Heft Quelle:25(2014), 11, Seite 2224-2229
ISSN Quelle:1569-8041
Abstract:BACKGROUND: The aim of this study was to investigate the impact of the high-dose regimen on the outcome of patients with follicular lymphoma (FL) having had autologous stem-cell transplantation (ASCT) in a recent time period. - PATIENTS: Between 1995 and 2007, 2233 patients with FL had their first ASCT with either a total body irradiation (TBI)-containing regimen or carmustin, etoposide, cytarabine and melphalan (BEAM), of which 47% were autografted in first remission. - RESULTS: After a median observation time of 73 months (interquartile range 30-107), 5- and 10-year non-relapse mortality (NRM) was similar (6% and 10% in both groups). No significant NRM differences became evident after multivariate adjustment for confounders. Secondary malignancies were observed in 9.7% and 7.9% of the patients after TBI and BEAM (P = 0.19), which were treatment-related myelodysplastic syndromes/acute myelogenous leukaemia (t-MDS/AML) in 3.4% and 2.8% (P = 0.57). The median time to t-MDS/AML was around 50 months in both groups. Because of a lower relapse incidence, TBI was associated with better event-free survival reaching statistical significance in the patients transplanted in first remission but not in those transplanted beyond first remission. - CONCLUSIONS: In patients with FL who received TBI-based ASCT after 1995 increased NRM and t-MDS/AML risks did not emerge compared with BEAM while disease control was at least equivalent.
DOI:doi:10.1093/annonc/mdu440
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1093/annonc/mdu440
 DOI: https://doi.org/10.1093/annonc/mdu440
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Adolescent
 Adult
 Aged
 Antibodies, Monoclonal, Murine-Derived
 Antineoplastic Combined Chemotherapy Protocols
 Carmustine
 Combined Modality Therapy
 Cytarabine
 Disease-Free Survival
 Female
 follicular lymphoma
 Humans
 Lymphoma, Follicular
 Male
 Melphalan
 Middle Aged
 Neoplasm Recurrence, Local
 Podophyllotoxin
 Remission Induction
 rituximab
 Rituximab
 secondary malignancies
 Stem Cell Transplantation
 t-MDS/AML
 total body irradiation
 transplantation
 Transplantation, Autologous
 Whole-Body Irradiation
 Young Adult
K10plus-PPN:1743118694
Verknüpfungen:→ Zeitschrift

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