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Verfasst von:Dösch, Andreas [VerfasserIn]   i
 Müller, Susanne [VerfasserIn]   i
 Akyol, Ceylan [VerfasserIn]   i
 Erbel, Christian [VerfasserIn]   i
 Frankenstein, Lutz [VerfasserIn]   i
 Ruhparwar, Arjang [VerfasserIn]   i
 Ehlermann, Philipp [VerfasserIn]   i
 Dengler, Thomas J [VerfasserIn]   i
 Katus, Hugo [VerfasserIn]   i
Titel:Increased adherence eight months after switch from twice daily calcineurin inhibitor based treatment to once daily modified released tacrolimus in heart transplantation
Verf.angabe:Andreas O Doesch, Susanne Mueller, Ceylan Akyol, Christian Erbel, Lutz Frankenstein, Arjang Ruhparwar, Philipp Ehlermann, Thomas J Dengler, Hugo A Katus
E-Jahr:2013
Jahr:18 October 2013
Umfang:6 S.
Fussnoten:Gesehen am 17.12.2020
Titel Quelle:Enthalten in: Drug design, development and therapy
Ort Quelle:Albany, Auckland : Dove Medical Press, 2007
Jahr Quelle:2013
Band/Heft Quelle:7(2013), Seite 1253-1258
ISSN Quelle:1177-8881
Abstract:Background - Modified-release tacrolimus (TAC) is a new, once-daily oral formulation of the established immunosuppressive agent TAC. This study evaluated long-term patient adherence, as well as safety and efficacy, in stable patients after heart transplantation (HTx) who switched from a conventional twice daily calcineurin inhibitor-based regimen (TAC or cyclosporine A [CsA]) to a once-daily modified-release TAC regimen. - - Methods - Stable patients were switched from conventional TAC or CsA (twice-daily dosing) to modified-release TAC (once-daily dosing) according to manufacturer’s recommendations using a pre-experimental design. Self-reported adherence was assessed at baseline and 8 months after the switch with the Basel Assessment of Adherence with Immunosuppressive Medication Scale (BAASIS). Additionally, routine laboratory values were analyzed 8 months after switch. - - Results - Of 76 patients (58 male, 18 female) initially included, 72 were available for statistical analysis, as modified-release TAC was discontinued due to diarrhea in one patient and gastrointestinal discomfort in three patients. Overall nonadherence at baseline for any of the four BAASIS items was 75.0% versus 40.3% after 8 months (P<0.0001). After 8 months, adherence was improved in 41 patients (56.9%), unchanged in 27 (37.5%), and reduced in four patients (5.6%). The BAASIS visual analog scale score improved significantly from 87.0% ± 13.5% to 97.5% ± 5.7% (P<0.0001). No significant changes were observed for hematological, renal, or liver function parameters after 8 months (all P=not significant). - - Conclusion - To our knowledge, this is the first study in stable patients after HTx to demonstrate a significant improvement in long-term (ie, 8-month) patient adherence after the switch to modified-release TAC. Modified-release TAC was generally well tolerated. Further studies are currently underway to investigate long-term safety after HTx of various calcineurin inhibitors for prevention of rejection and occurrence of side effects.
DOI:doi:10.2147/DDDT.S52820
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.2147/DDDT.S52820
 Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808207/
 DOI: https://doi.org/10.2147/DDDT.S52820
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1743125488
Verknüpfungen:→ Zeitschrift

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