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| Verfasst von: | Adutler-Lieber, Shimrit [VerfasserIn]  |
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| | Zaretsky, Irina [VerfasserIn] |
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| | Platzman, Ilia [VerfasserIn] |
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| | Deeg, Janosch A. [VerfasserIn] |
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| | Friedman, Nir [VerfasserIn] |
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| | Spatz, Joachim P. [VerfasserIn] |
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| | Geiger, Benjamin [VerfasserIn] |
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| Titel: | Engineering of synthetic cellular microenvironments |
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| Titelzusatz: | implications for immunity |
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| Verf.angabe: | Shimrit Adutler-Lieber, Irina Zaretsky, Ilia Platzman, Janosch Deeg, Nir Friedman, Joachim P. Spatz, Benjamin Geiger |
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| E-Jahr: | 2014 |
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| Jahr: | 18 June 2014 |
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| Umfang: | 12 S. |
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| Fussnoten: | Gesehen am 18.12.2020 |
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| Titel Quelle: | Enthalten in: Journal of autoimmunity |
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| Ort Quelle: | London : Academic Press, 1988 |
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| Jahr Quelle: | 2014 |
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| Band/Heft Quelle: | 54(2014), Seite 100-111 |
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| ISSN Quelle: | 1095-9157 |
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| Abstract: | In this article, we discuss novel synthetic approaches for studying the interactions of cells with their microenvironment. Notably, critical cellular processes such as growth, differentiation, migration, and fate determination, are tightly regulated by interactions with neighboring cells, and the surrounding extracellular matrix. Given the huge complexity of natural cellular environments, and their rich molecular and physical diversity, the mission of understanding "environmental signaling" at a molecular-mechanistic level appears to be extremely challenging. To meet these challenges, attempts have been made in recent years to design synthetic matrices with defined chemical and physical properties, which, artificial though they may be, could reveal basic "design principles" underlying the physiological processes. Here, we summarize recent developments in the characterization of the chemical and physical properties of cell sensing and adhesion, as well as the design and use of engineered, micro- to nanoscale patterned and confined environments, for systematic, comprehensive modulation of the cells' environment. The power of these biomimetic surfaces to highlight environmental signaling events in cells, and in immune cells in particular, will be discussed. |
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| DOI: | doi:10.1016/j.jaut.2014.05.003 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.jaut.2014.05.003 |
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| | DOI: https://doi.org/10.1016/j.jaut.2014.05.003 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Adhesion signaling |
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| | Animals |
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| | Antigen presentation |
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| | Biomimetic Materials |
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| | Biomimetics |
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| | Cell adhesion |
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| | Cell Adhesion |
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| | Cellular Microenvironment |
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| | Humans |
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| | Immune niche |
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| | Mechanobiology |
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| | Signal Transduction |
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| | Synthetic biology |
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| | Tissue Engineering |
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| K10plus-PPN: | 1743251165 |
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| Verknüpfungen: | → Zeitschrift |
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Engineering of synthetic cellular microenvironments / Adutler-Lieber, Shimrit [VerfasserIn]; 18 June 2014 (Online-Ressource)
