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Verfasst von:Gövert, Felix [VerfasserIn]   i
 Balint, Bettina [VerfasserIn]   i
Titel:Temporal discrimination is altered in patients with isolated asymmetric and jerky upper limb tremor
Verf.angabe:Felix Gövert, Jos Becktepe, Bettina Balint, Lorenzo Rocchi, Florian Brugger, Alicia Garrido, Tim Walter, Ricci Hannah, John Rothwell, Rodger Elble, Günther Deuschl, and Kailash Bhatia
Jahr:2020
Jahr des Originals:2019
Umfang:10 S.
Fussnoten:Published online: 13 November 2019 ; Gesehen am 21.12.2020
Titel Quelle:Enthalten in: Movement disorders
Ort Quelle:New York, NY : Wiley, 1986
Jahr Quelle:2020
Band/Heft Quelle:35(2020), 2, Seite 306-315
ISSN Quelle:1531-8257
Abstract:Background: Unilateral or very asymmetric upper limb tremors with a jerky appearance are poorly investigated. Their clinical classification is an unsolved problem because their classification as essential tremor versus dystonic tremor is uncertain. To avoid misclassification as essential tremor or premature classification as dystonic tremor, the term indeterminate tremor was suggested. Objectives: The aim of this study was to characterize this tremor subgroup electrophysiologically and evaluate whether diagnostically meaningful electrophysiological differences exist compared to patients with essential tremor and dystonic tremor. Methods: We enrolled 29 healthy subjects and 64 patients with tremor: 26 with dystonic tremor, 23 with essential tremor, and 15 patients with upper limb tremor resembling essential tremor but was unusually asymmetric and jerky (indeterminate tremor). We investigated the somatosensory temporal discrimination threshold, the short-interval intracortical inhibition, and the cortical plasticity by paired associative stimulation. Results: Somatosensory temporal discrimination threshold was significantly increased in patients with dystonic tremor and indeterminate tremor, but it was normal in the essential tremor patients and healthy controls. Significant differences in short-interval intracortical inhibition and paired associative stimulation were not found among the three patient groups and controls. Conclusion: These results indicate that indeterminate tremor, as defined in this study, shares electrophysiological similarities with dystonic tremor rather than essential tremor. Therefore, we propose that indeterminate tremor should be considered as a separate clinical entity from essential tremor and that it might be dystonic in nature. Somatosensory temporal discrimination appears to be a useful tool in tremor classification.
DOI:doi:10.1002/mds.27880
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/https://doi.org/10.1002/mds.27880
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/mds.27880
 DOI: https://doi.org/10.1002/mds.27880
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:dystonic tremor
 essential
 paired associative stimulation
 temporal discrimination
 tremor
K10plus-PPN:1743440855
Verknüpfungen:→ Zeitschrift

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