| |  Online-Ressource |
|---|
| Verfasst von: | Dreger, Peter [VerfasserIn]  |
|---|
| | Schnaiter, Andrea [VerfasserIn] |
|---|
| | Zenz, Thorsten [VerfasserIn] |
|---|
| | Böttcher, Sebastian [VerfasserIn] |
|---|
| | Rossi, Marianna [VerfasserIn] |
|---|
| | Paschka, Peter [VerfasserIn] |
|---|
| | Bühler, Andreas [VerfasserIn] |
|---|
| | Dietrich, Sascha [VerfasserIn] |
|---|
| | Busch, Raymonde [VerfasserIn] |
|---|
| | Ritgen, Matthias [VerfasserIn] |
|---|
| | Bunjes, Donald [VerfasserIn] |
|---|
| | Zeis, Matthias [VerfasserIn] |
|---|
| | Stadler, Michael [VerfasserIn] |
|---|
| | Uharek, Lutz [VerfasserIn] |
|---|
| | Scheid, Christof [VerfasserIn] |
|---|
| | Hegenbart, Ute [VerfasserIn] |
|---|
| | Hallek, Michael [VerfasserIn] |
|---|
| | Kneba, Michael [VerfasserIn] |
|---|
| | Schmitz, Norbert [VerfasserIn] |
|---|
| | Döhner, Hartmut [VerfasserIn] |
|---|
| | Stilgenbauer, Stephan [VerfasserIn] |
|---|
| Titel: | TP53, SF3B1, and NOTCH1 mutations and outcome of allotransplantation for chronic lymphocytic leukemia |
|---|
| Titelzusatz: | six-year follow-up of the GCLLSG CLL3X trial |
|---|
| Verf.angabe: | Peter Dreger, Andrea Schnaiter, Thorsten Zenz, Sebastian Böttcher, Marianna Rossi, Peter Paschka, Andreas Bühler, Sascha Dietrich, Raymonde Busch, Matthias Ritgen, Donald Bunjes, Matthias Zeis, Michael Stadler, Lutz Uharek, Christof Scheid, Ute Hegenbart, Michael Hallek, Michael Kneba, Norbert Schmitz, Hartmut Döhner, and Stephan Stilgenbauer |
|---|
| E-Jahr: | 2013 |
|---|
| Jahr: | February 22, 2013 |
|---|
| Umfang: | 5 S. |
|---|
| Fussnoten: | Gesehen am 04.01.2021 |
|---|
| Titel Quelle: | Enthalten in: Blood |
|---|
| Ort Quelle: | Washington, DC : American Society of Hematology, 1946 |
|---|
| Jahr Quelle: | 2013 |
|---|
| Band/Heft Quelle: | 121(2013), 16, Seite 3284-3288 |
|---|
| ISSN Quelle: | 1528-0020 |
|---|
| Abstract: | The purpose of this analysis was to provide 6-year follow-up of the CLL3X trial, which studied reduced-intensity allogeneic hematopoietic stem cell transplantation (HSCT) in patients with poor-risk chronic lymphocytic leukemia (CLL), and to investigate the effect of TP53, SF3B1, and NOTCH1 mutations on HSCT outcome. For 90 allografted patients, 6-year overall survival (OS) was 58% and 6-year event-free survival (EFS) was 38%. TP53, SF3B1, and NOTCH1 mutations were found in 30%, 26%, and 14% of the trial population, respectively. By univariate and multivariate analyses, the mutational status of the TP53, SF3B1, and NOTCH1 genes had no significant effect on OS and EFS. Studies of minimal residual disease confirmed durability of CLL eradication in mutated patients. We conclude that HSCT can provide long-term disease control in patients with poor-risk CLL independent of the presence of TP53, SF3B1, and NOTCH1 mutations. The trial has been registered at the US National Cancer Institute as #EU-20554, NCT00281983. |
|---|
| DOI: | doi:10.1182/blood-2012-11-469627 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1182/blood-2012-11-469627 |
|---|
| | DOI: https://doi.org/10.1182/blood-2012-11-469627 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| K10plus-PPN: | 1743816634 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
TP53, SF3B1, and NOTCH1 mutations and outcome of allotransplantation for chronic lymphocytic leukemia / Dreger, Peter [VerfasserIn]; February 22, 2013 (Online-Ressource)
