| |  Online-Ressource |
|---|
| Verfasst von: | Roider, Tobias [VerfasserIn]  |
|---|
| | Seufert, Julian [VerfasserIn] |
|---|
| | Uvarovskii, Alexey [VerfasserIn] |
|---|
| | Frauhammer, Felix [VerfasserIn] |
|---|
| | Bordas, Marie [VerfasserIn] |
|---|
| | Abedpour, Nima [VerfasserIn] |
|---|
| | Stolarczyk, Marta [VerfasserIn] |
|---|
| | Mallm, Jan-Philipp [VerfasserIn] |
|---|
| | Herbst, Sophie A. [VerfasserIn] |
|---|
| | Bruch, Peter-Martin [VerfasserIn] |
|---|
| | Balke-Want, Hyatt [VerfasserIn] |
|---|
| | Hundemer, Michael [VerfasserIn] |
|---|
| | Rippe, Karsten [VerfasserIn] |
|---|
| | Goeppert, Benjamin [VerfasserIn] |
|---|
| | Seiffert, Martina [VerfasserIn] |
|---|
| | Brors, Benedikt [VerfasserIn] |
|---|
| | Mechtersheimer, Gunhild [VerfasserIn] |
|---|
| | Zenz, Thorsten [VerfasserIn] |
|---|
| | Peifer, Martin [VerfasserIn] |
|---|
| | Chapuy, Björn [VerfasserIn] |
|---|
| | Schlesner, Matthias [VerfasserIn] |
|---|
| | Müller-Tidow, Carsten [VerfasserIn] |
|---|
| | Fröhling, Stefan [VerfasserIn] |
|---|
| | Huber, Wolfgang [VerfasserIn] |
|---|
| | Anders, Simon [VerfasserIn] |
|---|
| | Dietrich, Sascha [VerfasserIn] |
|---|
| Titel: | Dissecting intratumour heterogeneity of nodal B-cell lymphomas at the transcriptional, genetic and drug-response levels |
|---|
| Verf.angabe: | Tobias Roider, Julian Seufert, Alexey Uvarovskii, Felix Frauhammer, Marie Bordas, Nima Abedpour, Marta Stolarczyk, Jan-Philipp Mallm, Sophie A. Herbst, Peter-Martin Bruch, Hyatt Balke-Want, Michael Hundemer, Karsten Rippe, Benjamin Goeppert, Martina Seiffert, Benedikt Brors, Gunhild Mechtersheimer, Thorsten Zenz, Martin Peifer, Björn Chapuy, Matthias Schlesner, Carsten Müller-Tidow, Stefan Fröhling, Wolfgang Huber, Simon Anders and Sascha Dietrich |
|---|
| E-Jahr: | 2020 |
|---|
| Jahr: | 15 June 2020 |
|---|
| Umfang: | 11 S. |
|---|
| Fussnoten: | Gesehen am 05.01.2021 |
|---|
| Titel Quelle: | Enthalten in: Nature cell biology |
|---|
| Ort Quelle: | New York, NY : Nature America, 1999 |
|---|
| Jahr Quelle: | 2020 |
|---|
| Band/Heft Quelle: | 22(2020), 7, Seite 896-906 |
|---|
| ISSN Quelle: | 1476-4679 |
|---|
| Abstract: | Tumour heterogeneity encompasses both the malignant cells and their microenvironment. While heterogeneity between individual patients is known to affect the efficacy of cancer therapy, most personalized treatment approaches do not account for intratumour heterogeneity. We addressed this issue by studying the heterogeneity of nodal B-cell lymphomas by single-cell RNA-sequencing and transcriptome-informed flow cytometry. We identified transcriptionally distinct malignant subpopulations and compared their drug-response and genomic profiles. Malignant subpopulations from the same patient responded strikingly differently to anti-cancer drugs ex vivo, which recapitulated subpopulation-specific drug sensitivity during in vivo treatment. Infiltrating T cells represented the majority of non-malignant cells, whose gene-expression signatures were similar across all donors, whereas the frequencies of T-cell subsets varied significantly between the donors. Our data provide insights into the heterogeneity of nodal B-cell lymphomas and highlight the relevance of intratumour heterogeneity for personalized cancer therapy. |
|---|
| DOI: | doi:10.1038/s41556-020-0532-x |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/s41556-020-0532-x |
|---|
| | Volltext: https://www.nature.com/articles/s41556-020-0532-x |
|---|
| | DOI: https://doi.org/10.1038/s41556-020-0532-x |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Bibliogr. Hinweis: | Forschungsdaten: Roider, Tobias, 1988 - : Dissecting intratumor heterogeneity of nodal B cell lymphomas at transcriptional, genetic, and drug response levels |
|---|
| K10plus-PPN: | 1743896468 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Dissecting intratumour heterogeneity of nodal B-cell lymphomas at the transcriptional, genetic and drug-response levels / Roider, Tobias [VerfasserIn]; 15 June 2020 (Online-Ressource)
Andere Auflagen/Ausgaben