Ontogenesis of oxytocin pathways in the mammalian brain

• Verfasst von: Grinevich, Valéry [VerfasserIn]
• Verfasst von: Desarménien, Michel G. [VerfasserIn]
• Verfasst von: Chini, Bice [VerfasserIn]
• Verfasst von: Tauber, Maithé [VerfasserIn]
• Verfasst von: Muscatelli, Françoise [VerfasserIn]
• Titel: Ontogenesis of oxytocin pathways in the mammalian brain
• Titelzusatz: late maturation and psychosocial disorders
• Verf.angabe: Valery Grinevich, Michel G. Desarménien, Bice Chini, Maithé Tauber and Françoise Muscatelli
• E-Jahr: 2015
• Jahr: 20 January 2015
• Umfang: 18 S.
• Fussnoten: Gesehen am 07.01.2021
• Titel Quelle: Enthalten in: Frontiers in neuroanatomy
• Ort Quelle: Lausanne : Frontiers Research Foundation, 2007
• Jahr Quelle: 2015
• Band/Heft Quelle: 8(2015) Article 164, 18 Seiten
• ISSN Quelle: 1662-5129
• DOI: doi:10.3389/fnana.2014.00164
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: autisn
• Sach-SW: axonal release
• Sach-SW: ontogenesis
• Sach-SW: Oxytocin
• Sach-SW: oxytocin receptor
• Sach-SW: Prader-Willi Syndrome
• Sach-SW: somatodendritic release
• K10plus-PPN: 1744147167

Abstract

Oxytocin (OT), the main neuropeptide of sociality, is expressed in neurons exclusively localized in the hypothalamus. During the last decade, a plethora of neuroendocrine, metabolic, autonomic and behavioral effects of OT has been reported. In the urgency to find treatments to syndromes as invalidating as autism, many clinical trials have been launched in which OT is administered to patients, including adolescents and children. However, the impact of OT on the developing brain and in particular on the embryonic and early postnatal maturation of OT neurons, has been only poorly investigated. In the present review we summarize available (although limited) literature on general features of ontogenetic transformation of the OT system, including determination, migration and differentiation of OT neurons. Next, we discuss trajectories of OT receptors (OTR) in perinatal period. Furthermore, we provide evidence that early alterations, from birth, in the central OT system lead to severe neurodevelopmental diseases such as feeding deficit in infancy and severe defects in social behavior in adulthood, as described in Prader-Willi syndrome. Our review intends to propose a hypothesis about developmental dynamics of central OT pathways, which are essential for survival right after birth and for the acquisition of social skills later on. A better understanding of the embryonic and early postnatal maturation of the OT system may lead to better OT-based treatments in Prader-Willi syndrome and autism.