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Verfasst von:Dapunt, Ulrike A. [VerfasserIn]   i
 Prior, Birgit [VerfasserIn]   i
 Kretzer, Jan Philippe [VerfasserIn]   i
 Giese, Thomas [VerfasserIn]   i
 Zhao, Yina [VerfasserIn]   i
Titel:Bacterial biofilm components induce an enhanced inflammatory response against metal wear particles
Verf.angabe:Ulrike Dapunt, Birgit Prior, Jan Philippe Kretzer, Thomas Giese, Yina Zhao
E-Jahr:2020
Jahr:8 December 2020
Umfang:10 S.
Fussnoten:Gesehen am 08.01.2021
Titel Quelle:Enthalten in: Therapeutics and clinical risk management
Ort Quelle:Albany, Auckland : Dove Medical Press, 2005
Jahr Quelle:2020
Band/Heft Quelle:16(2020), Seite 1203-1212
ISSN Quelle:1178-203X
Abstract:Purpose - Aseptic implant loosening is still a feared complication in the field of orthopaedics. Presumably, a chronic inflammatory response is induced by wear particles, which leads to osteoclast generation, bone degradation and hence loosening of the implant. Since it has been demonstrated in the literature that most implants are in fact colonized by bacteria, the question arises whether aseptic implant loosening is truly aseptic. The aim of this study was to investigate a possibly enhanced inflammatory response to metal wear particles in the context of subclinical infection. - - Patients and Methods - Tissue samples were collected intra-operatively from patients undergoing implant-exchange surgery due to aseptic loosening. Histopathological analysis was performed, as well as gene expression analysis for the pro-inflammatory cytokine Interleukin-8. By a series of in vitro experiments, the effect of metal wear particles on human monocytes, polymorphonuclear neutrophiles and osteoblasts was investigated. Additionally, minor amounts of lipoteichoic acid (LTA) and the bacterial heat shock protein GroEL were added. - - Results - Histopathology of tissue samples revealed an accumulation of metal wear particles, as well as a cellular infiltrate consisting predominately of mononuclear cells. Furthermore, high expression of IL-8 could be detected in tissue surrounding the implant. Monocytes and osteoblasts in particular showed an increased release of IL-8 after stimulation with metal wear particles and in particular after stimulation with bacterial components and wear particles together. - - Conclusion - We were able to show that minor amounts of bacterial components and metal wear particles together induce an enhanced inflammatory response in human monocytes and osteoblasts. This effect could significantly contribute to the generation of bone-resorbing osteoclasts and hence implant-loosening.
DOI:doi:10.2147/TCRM.S280042
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.2147/TCRM.S280042
 Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733385/
 DOI: https://doi.org/10.2147/TCRM.S280042
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1744216525
Verknüpfungen:→ Zeitschrift

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