MiR-9 and the midbrain-hindbrain boundary

• Verfasst von: Alwin Prem Anand, A. [VerfasserIn]
• Verfasst von: Alvarez-Bolado, Gonzalo [VerfasserIn]
• Verfasst von: Wizenmann, Andrea [VerfasserIn]
• Titel: MiR-9 and the midbrain-hindbrain boundary
• Titelzusatz: a showcase for the limited functional conservation and regulatory complexity of microRNAs
• Verf.angabe: A. Alwin Prem Anand, Gonzalo Alvarez-Bolado and Andrea Wizenmann
• E-Jahr: 2020
• Jahr: 23 November 2020
• Umfang: 6 S.
• Fussnoten: Gesehen am 08.01.2021
• Titel Quelle: Enthalten in: Frontiers in cell and developmental biology
• Ort Quelle: Lausanne : Frontiers Media, 2013
• Jahr Quelle: 2020
• Band/Heft Quelle: 8(2020) Artikel-Nummer 586158, 6 Seiten
• ISSN Quelle: 2296-634X
• DOI: doi:10.3389/fcell.2020.586158
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Danio
• Sach-SW: Fgf8
• Sach-SW: Gallus
• Sach-SW: hairy-1
• Sach-SW: mid-hindbrain baundary
• Sach-SW: miR-9
• Sach-SW: neural developent
• Sach-SW: neural development mechanism
• Sach-SW: Xenopus
• K10plus-PPN: 1744222541

Abstract

MicroRNAs regulate gene expression at posttranscriptional levels. Some of them appear to regulate brain development and are involved in neurodevelopmental disorders. This has led to the suggestion that the role of microRNAs in neuronal de-velopment and function may be more central than previously appreciated. Here, we review the data about miR-9 function to depict how complex and subtle the functional conservation of this essential developmental regulatory system. On this basis, we propose that species-specific actions of miR-9 could underlie to a large degree spe-cies differences in brain size, shape and function.