| |  Online-Ressource |
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| Verfasst von: | Eichhorn, Tolga [VerfasserIn]  |
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| | Winter, Dominic [VerfasserIn] |
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| | Büchele, Berthold [VerfasserIn] |
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| | Dirdjaja, Natalie [VerfasserIn] |
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| | Frank, Martin [VerfasserIn] |
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| | Lehmann, Wolf-Dieter [VerfasserIn] |
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| | Mertens, Rolf [VerfasserIn] |
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| | Krauth-Siegel, Renate [VerfasserIn] |
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| | Simmet, Thomas [VerfasserIn] |
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| | Granzin, Joachim [VerfasserIn] |
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| | Efferth, Thomas [VerfasserIn] |
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| Titel: | Molecular interaction of artemisinin with translationally controlled tumor protein (TCTP) of Plasmodium falciparum |
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| Verf.angabe: | Tolga Eichhorn, Dominic Winter, Berthold Büchele, Natalie Dirdjaja, Martin Frank, Wolf-Dieter Lehmann, Rolf Mertens, R. Luise Krauth-Siegel, Thomas Simmet, Joachim Granzin, Thomas Efferth |
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| Jahr: | 2013 |
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| Jahr des Originals: | 2012 |
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| Umfang: | 8 S. |
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| Fussnoten: | Available online 17 October 2012 ; Gesehen am 08.01.2021 |
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| Titel Quelle: | Enthalten in: Biochemical pharmacology |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1958 |
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| Jahr Quelle: | 2013 |
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| Band/Heft Quelle: | 85(2013), 1, Seite 38-45 |
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| ISSN Quelle: | 1873-2968 |
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| Abstract: | Malaria causes millions of death cases per year. Since Plasmodium falciparum rapidly develops drug resistance, it is of high importance to investigate potential drug targets which may lead to novel rational therapy approaches. Here we report on the interaction of translationally controlled tumor protein of P. falciparum (PfTCTP) with the anti-malarial drug artemisinin. Furthermore, we investigated the crystal structure of PfTCTP. Using mass spectrometry, bioinformatic approaches and surface plasmon resonance spectroscopy, we identified novel binding sites of artemisinin which are in direct neighborhood to amino acids 19-46, 108-134 and 140-163. The regions covered by these residues are known to be functionally important for TCTP function. We conclude that interaction of artemisinin with TCTP may be at least in part explain the antimalarial activity of artemisinin. |
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| DOI: | doi:10.1016/j.bcp.2012.10.006 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.bcp.2012.10.006 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S0006295212006788 |
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| | DOI: https://doi.org/10.1016/j.bcp.2012.10.006 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Artemisinin |
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| | Translationally controlled tumor protein |
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| K10plus-PPN: | 1744271550 |
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| Verknüpfungen: | → Zeitschrift |
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Molecular interaction of artemisinin with translationally controlled tumor protein (TCTP) of Plasmodium falciparum / Eichhorn, Tolga [VerfasserIn]; 2013 (Online-Ressource)
