Exocyclic DNA adducts as oxidative stress markers in colon carcinogenesis

• Verfasst von: Bartsch, Helmut [VerfasserIn]
• Verfasst von: Nair, Jagadeesan [VerfasserIn]
• Verfasst von: Owen, Robert [VerfasserIn]
• Titel: Exocyclic DNA adducts as oxidative stress markers in colon carcinogenesis
• Titelzusatz: potential role of lipid peroxidation, dietary fat and antioxidants
• Verf.angabe: Helmut Bartsch, Jagadeesan Nair and Robert W. Owen
• E-Jahr: 2005
• Jahr: 01.06.2005
• Jahr des Originals: 2002
• Umfang: 7 S.
• Fussnoten: Gesehen am 12.01.2021 ; Elektronische Reproduktion der Druck-Ausgabe
• Titel Quelle: Enthalten in: Biological chemistry
• Ort Quelle: Berlin [u.a.] : de Gruyter, 1996
• Jahr Quelle: 2002
• Band/Heft Quelle: 383(2002), 6, Seite 915-921
• ISSN Quelle: 1437-4315
• DOI: doi:10.1515/BC.2002.098
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1744399638

Abstract

<section class="abstract"><h2 class="abstractTitle text-title my-1" id="d2156e2">Abstract</h2><p>Molecular pathways to colorectal cancer involve multiple - genetic changes, whereby extensive oxyradical - damage causes mutations in cancerrelated genes - and leads to a cycle of cell death and regeneration. Besides - direct oxidative DNAdamage, reactive oxygen - and nitrogen species can induce etheno ()DNA - adducts mainly via trans-4-hydroxy-2-nonenal, generated - as the major aldehyde by lipid peroxidation (LPO) - of ω-6 PUFAs. Patients with familial adenomatous - polyposis (FAP) develop multiple colorectal adenomas. - In affected tissues increased LPO could be triggered - due to increased arachidonic acid metabolism - as a result of elevated cyclooxygenases. Our studies - demonstrated an increased DNA adduct level in affected - colon epithelia of FAP patients. DNA adducts - are promutagenic and can cause genomic instability - that drives colorectal adenoma to malignancy. We - have further investigated the potential chemopreventive - properties of olive oil and its polyphenolic components. - Mediterranean diet, of which olive oil is a major - fatty acid source, has protective effects against human - breast and colorectal cancers. Olive oil extracts - and the newly identified lignan fractions showed high - antioxidant capacity in vitro. As DNA adducts are - biomarkers for oxidative stress and LPO induced DNA - damage, they can verify the efficacy of newly identified - antioxidants, e.g. from olive oil, as chemopreventive - agents against colon carcinogenesis.</p></section>