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Status: Bibliographieeintrag

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Verfasst von:Liebl, Florian [VerfasserIn]   i
 Demir, Ihsan Ekin [VerfasserIn]   i
 Mayer, Katharina [VerfasserIn]   i
 Schuster, Tibor [VerfasserIn]   i
 DʼHaese, Jan G. [VerfasserIn]   i
 Becker, Karen [VerfasserIn]   i
 Langer, Rupert [VerfasserIn]   i
 Bergmann, Frank [VerfasserIn]   i
 Wang, Kun [VerfasserIn]   i
 Rosenberg, Robert [VerfasserIn]   i
 Novotny, Alexander R. [VerfasserIn]   i
 Feith, Marcus [VerfasserIn]   i
 Reim, Daniel [VerfasserIn]   i
 Friess, Helmut [VerfasserIn]   i
 Ceyhan, Güralp O. [VerfasserIn]   i
Titel:The impact of neural invasion severity in gastrointestinal malignancies
Titelzusatz:a clinicopathological study
Verf.angabe:Florian Liebl, Ihsan Ekin Demir, Katharina Mayer, Tibor Schuster, Jan G. DʼHaese, Karen Becker, Rupert Langer, Frank Bergmann, Kun Wang, Robert Rosenberg, Alexander R. Novotny, Marcus Feith, Daniel Reim, Helmut Friess, and Güralp O. Ceyhan
Jahr:2014
Umfang:9 S.
Fussnoten:Gesehen am 13.01.2021
Titel Quelle:Enthalten in: Annals of surgery
Ort Quelle:[S.l.] : Lippincott Williams & Wilkins, 1885
Jahr Quelle:2014
Band/Heft Quelle:260(2014), 5, Seite 900-908
ISSN Quelle:1528-1140
Abstract:OBJECTIVES: Because neural invasion (NI) is still inconsistently reported and not well characterized within gastrointestinal malignancies (GIMs), our aim was to determine the exact prevalence and severity of NI and to elucidate the true impact of NI on patient's prognosis. - BACKGROUND: The union internationale contre le cancer (UICC) recently added NI as a novel parameter in the current TNM classification. However, there are only a few existing studies with specific focus on NI, so that the distinct role of NI in GIMs is still uncertain. - MATERIALS AND METHODS: NI was characterized in approximately 16,000 hematoxylin and eosin tissue sections from 2050 patients with adenocarcinoma of the esophagogastric junction (AEG)-I-III, squamous cell carcinoma (SCC) of the esophagus, gastric cancer (GC), colon cancer (CC), rectal cancer (RC), cholangiocellular cancer (CCC), hepatocellular cancer (HCC), and pancreatic cancer (PC). NI prevalence and severity was determined and related to patient's prognosis and survival. - RESULTS: NI prevalence largely varied between HCC/6%, CC/28%, RC/34%, AEG-I/36% and AEG-II/36%, SCC/37%, GC/38%, CCC/58%, and AEG-III/65% to PC/100%. NI severity score was uppermost in PC (24.9±1.9) and lowest in AEG-I (0.8±0.3). Multivariable analyses including age, sex, TNM stage, and grading revealed that the prevalence of NI was significantly associated with diminished survival in AEG-II/III, GC, and RC. However, increasing NI severity impaired survival in AEG-II/III and PC only. - CONCLUSIONS: NI prevalence and NI severity strongly vary within GIMs. Determination of NI severity in GIMs is a more precise tool than solely recording the presence of NI and revealed dismal prognostic impact on patients with AEG-II/III and PC. Evidently, NI is not a concomitant side feature in GIMs and, therefore, deserves special attention for improved patient stratification and individualized therapy after surgery.
DOI:doi:10.1097/SLA.0000000000000968
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1097/SLA.0000000000000968
 DOI: https://doi.org/10.1097/SLA.0000000000000968
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Aged
 Aged, 80 and over
 Female
 Gastrointestinal Neoplasms
 Humans
 Male
 Middle Aged
 Neoplasm Grading
 Neoplasm Invasiveness
 Neoplasm Staging
 Nerve Tissue
 Prevalence
 Severity of Illness Index
 Survival Rate
K10plus-PPN:1744534624
Verknüpfungen:→ Zeitschrift

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