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| Verfasst von: | Waldsperger, Hanna [VerfasserIn]  |
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| | Biener, Moritz [VerfasserIn] |
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| | Stoyanov, Kiril M. [VerfasserIn] |
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| | Vafaie, Mehrshad [VerfasserIn] |
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| | Katus, Hugo [VerfasserIn] |
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| | Giannitsis, Evangelos [VerfasserIn] |
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| | Müller-Hennessen, Matthias [VerfasserIn] |
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| Titel: | Prognostic value of elevated copeptin and high-sensitivity cardiac troponin T in patients with and without acute coronary syndrome |
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| Titelzusatz: | the ConTrACS study |
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| Verf.angabe: | Hanna Waldsperger, Moritz Biener, Kiril M. Stoyanov, Mehrshad Vafaie, Hugo A. Katus, Evangelos Giannitsis and Matthias Mueller-Hennessen |
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| E-Jahr: | 2020 |
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| Jahr: | 11 November 2020 |
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| Fussnoten: | Gesehen am 13.01.2021 |
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| Titel Quelle: | Enthalten in: Journal of Clinical Medicine |
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| Ort Quelle: | Basel : MDPI, 2012 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 9(2020,11) Artikel-Nummer 3627, 12 Seiten |
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| ISSN Quelle: | 2077-0383 |
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| Abstract: | Aims: We aimed to assess the prognostic role of copeptin in patients presenting to the emergency department with acute symptoms and increased high-sensitivity cardiac troponin T. Methods: A total of 3890 patients presenting with acute symptoms to the emergency department of Heidelberg University Hospital were assessed for increased hs-cTnT (>14 ng/L) from three cohorts: the Heidelberg Acute Coronary Syndrome (ACS) Registry (n = 2477), the BIOPS Registry (n = 320), and the ACS OMICS Registry (n = 1093). In a pooled analysis, 1956 patients remained, comprising of 1600 patients with ACS and 356 patients with non-ACS. Results: Median follow-up was 1468 days in the ACS cohort and 709 days in the non-ACS cohort. Elevated copeptin levels (>10 pmol/L) were found in 1174 patients (60.0%) in the entire cohort (58.1% in ACS and 68.5% in non-ACS, respectively) and mortality rates were significantly higher than in patients with normal copeptin levels (29.0% vs. 10.7%, p < 0.001). In a multivariate Cox regression, elevated copeptin was independently associated with all-cause death in the ACS (HR = 1.7, 1.3–2.3, p = 0.002) and non-ACS cohort (HR = 2.7, 1.4–5.0, p = 0.0018). Conclusion: Copeptin may aid in identifying patients at risk for adverse outcomes in patients with increased levels of hs-cTnT in ACS patients and in non-ACS conditions. |
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| DOI: | doi:10.3390/jcm9113627 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.3390/jcm9113627 |
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| | Volltext: https://www.mdpi.com/2077-0383/9/11/3627 |
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| | DOI: https://doi.org/10.3390/jcm9113627 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | acute coronary syndrome |
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| | cardiac troponin |
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| | copeptin |
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| | emergency department |
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| | high sensitivity |
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| | prognosis |
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| | risk stratification |
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| K10plus-PPN: | 1744591210 |
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| Verknüpfungen: | → Zeitschrift |
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Prognostic value of elevated copeptin and high-sensitivity cardiac troponin T in patients with and without acute coronary syndrome / Waldsperger, Hanna [VerfasserIn]; 11 November 2020 (Online-Ressource)
