Mechanisms of mitogen-activated protein kinase inhibition by parathyroid hormone in osteoblast-like cells

• Verfasst von: Hömme, Meike [VerfasserIn]
• Verfasst von: Schmitt, Claus P. [VerfasserIn]
• Verfasst von: Mehls, Otto [VerfasserIn]
• Verfasst von: Schaefer, Franz [VerfasserIn]
• Titel: Mechanisms of mitogen-activated protein kinase inhibition by parathyroid hormone in osteoblast-like cells
• Verf.angabe: Meike Hömme, Claus P. Schmitt, Otto Mehls, and Franz Schaefer
• E-Jahr: 2004
• Jahr: October 25, 2004
• Umfang: 7 S.
• Fussnoten: Gesehen am 15.01.2021
• Titel Quelle: Enthalten in: American Society of NephrologyJournal of the American Society of Nephrology
• Ort Quelle: Washington, DC : American Society of Nephrology, 1990
• Jahr Quelle: 2004
• Band/Heft Quelle: 15(2004), 11, Seite 2844-2850
• ISSN Quelle: 1533-3450
• DOI: doi:10.1097/01.ASN.0000143472.13214.2C
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1744735867

Abstract

Parathyroid hormone (PTH) dose dependently inhibits growth factor- and stress-induced osteoblast proliferation via inactivating mitogen-activated protein kinase (MAPK) signaling pathways. Osteoblasts have recently been shown to express MAPK phosphatase (MKP)-1, a dual-specific phosphatase inactivator of MAPK. Investigated was the role of MKPs in the PTH-induced attenuation of MAPK and Jun N-terminal kinase (JNK) signaling in osteoblast-like UMR106-01 cells.