Chronic uremia attenuates growth hormone-induced signal transduction in skeletal muscle

• Verfasst von: Sun, Di Fei [VerfasserIn]
• Verfasst von: Zheng, Zhilan [VerfasserIn]
• Verfasst von: Tummala, Padmaja [VerfasserIn]
• Verfasst von: Oh, Jun [VerfasserIn]
• Verfasst von: Schaefer, Franz [VerfasserIn]
• Verfasst von: Rabkin, Ralph [VerfasserIn]
• Titel: Chronic uremia attenuates growth hormone-induced signal transduction in skeletal muscle
• Verf.angabe: Di Fei Sun, Zhilan Zheng, Padmaja Tummala, Jun Oh, Franz Schaefer, and Ralph Rabkin
• E-Jahr: 2004
• Jahr: October 1, 2004
• Umfang: 7 S.
• Fussnoten: Gesehen am 15.01.2021
• Titel Quelle: Enthalten in: American Society of NephrologyJournal of the American Society of Nephrology
• Ort Quelle: Washington, DC : American Society of Nephrology, 1990
• Jahr Quelle: 2004
• Band/Heft Quelle: 15(2004), 10, Seite 2630-2636
• ISSN Quelle: 1533-3450
• DOI: doi:10.1097/01.ASN.0000139492.36400.6C
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1744737193

Abstract

Malnutrition and muscle wasting are common in chronic renal failure (CRF) and adversely affect morbidity and mortality. Contributing to the muscle wasting is resistance to growth hormone (GH). For testing whether impaired GH signaling is a cause of the skeletal muscle GH resistance and for elucidating its mechanisms, muscle GH signaling and action were studied in GH-deficient rats with surgically induced CRF and sham-operated pairfed control rats.