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Verfasst von:Melnik, Svitlana [VerfasserIn]   i
 Gabler, Jessica [VerfasserIn]   i
 Dreher, Simon I. [VerfasserIn]   i
 Hecht, Nicole [VerfasserIn]   i
 Hofmann, Nina [VerfasserIn]   i
 Großner, Tobias [VerfasserIn]   i
 Richter, Wiltrud [VerfasserIn]   i
Titel:MiR-218 affects hypertrophic differentiation of human mesenchymal stromal cells during chondrogenesis via targeting RUNX2, MEF2C, and COL10A1
Verf.angabe:Svitlana Melnik, Jessica Gabler, Simon I. Dreher, Nicole Hecht, Nina Hofmann, Tobias Großner and Wiltrud Richter
E-Jahr:2020
Jahr:10 December 2020
Umfang:18 S.
Fussnoten:Gesehen am 18.01.2021
Titel Quelle:Enthalten in: Stem cell research & therapy
Ort Quelle:London : BioMed Central, 2010
Jahr Quelle:2020
Band/Heft Quelle:11(2020), Artikel-ID 532, Seite 1-18
ISSN Quelle:1757-6512
Abstract:Human mesenchymal stromal cells (MSC) hold hopes for cartilage regenerative therapy due to their chondrogenic differentiation potential. However, undesirable occurrence of calcification after ectopic transplantation, known as hypertrophic degeneration, remains the major obstacle limiting application of MSC in cartilage tissue regeneration approaches. There is growing evidence that microRNAs (miRs) play essential roles in post-transcriptional regulation of hypertrophic differentiation during chondrogenesis. Aim of the study was to identify new miR candidates involved in repression of hypertrophy-related targets.
DOI:doi:10.1186/s13287-020-02026-6
URL:kostenfrei: Volltext: https://doi.org/10.1186/s13287-020-02026-6
 DOI: https://doi.org/10.1186/s13287-020-02026-6
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Chondrocyte hypertrophy
 Collagen type X
 MEF2C
 Mesenchymal stromal cells (MSC)
 miR-218
 Osteoarthritis (OA)
 RUNX2
K10plus-PPN:1744853908
Verknüpfungen:→ Zeitschrift
 
 
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