Prevalence of a first-degree relative with colorectal cancer and uptake of screening among persons 40 to 54 years old

• Verfasst von: Weigl, Korbinian [VerfasserIn]
• Verfasst von: Tikk, Kaja [VerfasserIn]
• Verfasst von: Hoffmeister, Michael [VerfasserIn]
• Verfasst von: Kolligs, Frank Thomas [VerfasserIn]
• Verfasst von: Schweigler, Dirk [VerfasserIn]
• Verfasst von: Brenner, Hermann [VerfasserIn]
• Titel: Prevalence of a first-degree relative with colorectal cancer and uptake of screening among persons 40 to 54 years old
• Verf.angabe: Korbinian Weigl, Kaja Tikk, Michael Hoffmeister, Jochen Hampe, Svitlana Igel, Frank Kolligs, Stefanie J. Klug, Ulrich Mansmann, Oliver Müller, Jutta M. Nagel, Marcus Pichler, Matthias Schwab, Dirk Schweigler, Anna-Magdalena Stephan, Enrico N. De Toni, Hermann Brenner
• Jahr: 2020
• Umfang: 12 S.
• Fussnoten: Available online 4 December 2019 ; Gesehen am 26.10.2021
• Titel Quelle: Enthalten in: Clinical gastroenterology and hepatology
• Ort Quelle: New York, NY : Elsevier Science, 2003
• Jahr Quelle: 2020
• Band/Heft Quelle: 18(2020), 11, Seite 2535-2543, e1-e3
• ISSN Quelle: 1542-7714
• DOI: doi:10.1016/j.cgh.2019.11.044
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Colorectal Neoplasms
• Sach-SW: Family History
• Sach-SW: Screening
• K10plus-PPN: 1744898952

Abstract

Background & Aims - People with a first-degree relative with colorectal cancer (CRC) are recommended to start CRC screening at age 40. However, there is limited information on how many people in different age groups have a known family history of CRC and how many of them have had a colonoscopy. - Methods - We set up a multicenter, cross-sectional, population-based study in Germany to determine what proportions of persons in age groups from 40 to 54 years old have a known family history of CRC. We invited 160,000 persons to participate in an online survey from 2015 through 2016. We investigated what proportions of persons in each age group reported a family history of CRC and what proportions of persons underwent a colonoscopy examination using descriptive statistics and multiple logistic regression models. - Results - Of 28,711 responders to the online questionnaire (8428 were age 40-44 years, 9879 were age 45-49 years, and 10,404 were age 50-54 years), 2705 stated that they had a first-degree relative with CRC (9.4%). The prevalence of a first-degree relative with CRC increased with age: 7.5%, 9.6%, and 10.9% for people 40 to 44 years old, 45 to 49 years old, and 50 to 54 years old, respectively. The prevalence of a first-degree relative who received a diagnosis of CRC at age 70 years or older increased steadily with each age group. Although a greater proportion of people with a family history of CRC had undergone a colonoscopy examination (54.5%) than people without a family history of CRC (25.7%; P < .0001), large proportions of people within this risk group were not in compliance with the guidelines (54.8%, 47.6%, and 38.6% for ages 40-44 y, 45-49 y, and 50-54 y, respectively). - Conclusions - One in 10 persons in Germany age 40 to 54 years old has a first-degree relative with CRC. Guidelines recommend initiation of screening at ages 40 to 45 years for people with a family history, yet at this age many people do not have a family history of CRC yet, and almost half of persons 40 to 54 years old with a family history of CRC have not yet received a screening colonoscopy.